Spontaneous medication-related osteonecrosis of the jaws in a 23-year-Old

Brenden J. Manley, Timothy W. Neal, Shyam Indrakanti, Thomas Schlieve

Research output: Contribution to journalArticlepeer-review


Medication-related osteonecrosis is a well-documented yet rare complication of antiresorptive treatment. The risk of MRONJ is well established in the adult population but has yet to be established in the pediatric population. Additionally, the risk to this population in adulthood following many years of antiresorptive use is unknown. This case report describes a patient who received long-term antiresorptive medication as an adolescent and spontaneously developed MRONJ at age 23. To the authors’ knowledge, this is the youngest patient with MRONJ reported in the literature.

Original languageEnglish (US)
Article number100289
JournalOral and Maxillofacial Surgery Cases
Issue number1
StatePublished - Mar 2023


  • Antiresorptive
  • Bisphosphonate
  • Osteonecrosis

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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