Specificity of the Bacteriophage PBS2 Induced Inhibitor of Uracil-DNA Glycosylase

Peter Karran, Richard Cone, Errol C. Friedberg

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The purified PBS2 phage-coded inhibitor of uracil-DNA glycosylase (Ura-DNA glycosylase) from Bacillus subtilis has been tested for its ability to inhibit this enzyme isolated from other prokaryotic and from eukaryotic sources. In addition, the inhibitor has been assayed for its effect on DNA glycosylases specific for other base residues in DNA. The data indicate that Ura-DNA glycosylases from a variety of sources are equally sensitive to inhibition by the inhibitor. DNA glycosylases specific for base residues in DNA other than uracil are not inhibited by the PBS2-coded inhibitor.

Original languageEnglish (US)
Pages (from-to)6092-6096
Number of pages5
Issue number21
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Biochemistry


Dive into the research topics of 'Specificity of the Bacteriophage PBS2 Induced Inhibitor of Uracil-DNA Glycosylase'. Together they form a unique fingerprint.

Cite this