Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus

Laurent Gautron; Michel Chaigniau; Sophie Layé

doi:10.1016/j.brainres.2003.09.061

Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus

Laurent Gautron, Michel Chaigniau, Sophie Layé

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain.

Original language	English (US)
Pages (from-to)	260-264
Number of pages	5
Journal	Brain Research
Volume	994
Issue number	2
DOIs	https://doi.org/10.1016/j.brainres.2003.09.061
State	Published - Dec 24 2003

Keywords

Cytokines
Hypothalamus
Immunohistochemistry
Oxytocin
Transcription factor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2003.09.061

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title = "Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus",

abstract = "The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain.",

keywords = "Cytokines, Hypothalamus, Immunohistochemistry, Oxytocin, Transcription factor",

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AU - Gautron, Laurent

AU - Chaigniau, Michel

AU - Layé, Sophie

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Y1 - 2003/12/24

N2 - The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain.

AB - The transcription factor STAT1 participates in signaling pathways and cellular responses triggered by several cytokines, growth factors and hormones. The present work demonstrates for the first time the immunohistochemical distribution of STAT1 in the rat hypothalamus. STAT1 immunoreactivity was observed in somas, dendrites and axons of neurons throughout the supraoptic and paraventricular nuclei and co-localized specifically with oxytocin. These findings indicate that STAT1 is positioned to participate in specific neuroendocrine regulation in the nonpathological rat brain.

KW - Cytokines

KW - Hypothalamus

KW - Immunohistochemistry

KW - Oxytocin

KW - Transcription factor

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EP - 264

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus

Abstract

Keywords

ASJC Scopus subject areas

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