Spatially fractionated (GRID) therapy for large and bulky tumors.

José A. Peñagarícano, Robert Griffin, Peter Corry, Eduardo Moros, Yulong Yan, Vaneerat Ratanatharathorn

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Avanced bulky tumors warrant aggressive therapy to attempt to maximize local control of the disease. Spatially fractionated radiation therapy (GRID) delivers a single-fraction of high dose radiation to these tumors with a curative or palliative goal. GRID therapy may be combined with fractionated radiation therapy or used in a therapeutic multi-modality setting to achieve control of the bulky disease. Current clinical data confirms the value of GRID therapy in the management of large volume of disease with an acceptable toxicity profile. GRID therapy has broad systemic effects leading to increases in a variety of cytokines that correlate with clinical outcome.

Original languageEnglish (US)
Pages (from-to)263-265
Number of pages3
JournalThe Journal of the Arkansas Medical Society
Issue number11
StatePublished - May 1 2009

ASJC Scopus subject areas

  • Medicine(all)


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