TY - JOUR
T1 - Southwestern internal medicine conference
T2 - Shiga-like toxins in hemolytic- uremic syndrome and thrombotic thrombocytopenic purpura
AU - Hofmann, S. L.
PY - 1993
Y1 - 1993
N2 - The majority of cases of hemolytic-uremic syndrome and a smaller proportion of cases of thrombotic thrombocytopenic purpura have recently been shown to result from a toxin produced by enteric bacteria, referred to as verotoxin, or Shiga-like toxin. The predominant toxin-producing bacterial strain in North America is E. coli O157:H7, which causes hemorrhagic colitis in humans after ingestion of contaminated meat. The toxin is believed to gain entry to the circulation from the bowel wall; it then binds to specific glycolipid receptors abundant on renal vascular endothelial cells. The toxin inactivates ribosomes inside the cells, thereby killing them and producing the clinical manifestations of hemolytic-uremic syndrome. Recognition of the etiology of hemolytic-uremic syndrome may lead to better prospects for prevention and treatment.
AB - The majority of cases of hemolytic-uremic syndrome and a smaller proportion of cases of thrombotic thrombocytopenic purpura have recently been shown to result from a toxin produced by enteric bacteria, referred to as verotoxin, or Shiga-like toxin. The predominant toxin-producing bacterial strain in North America is E. coli O157:H7, which causes hemorrhagic colitis in humans after ingestion of contaminated meat. The toxin is believed to gain entry to the circulation from the bowel wall; it then binds to specific glycolipid receptors abundant on renal vascular endothelial cells. The toxin inactivates ribosomes inside the cells, thereby killing them and producing the clinical manifestations of hemolytic-uremic syndrome. Recognition of the etiology of hemolytic-uremic syndrome may lead to better prospects for prevention and treatment.
UR - http://www.scopus.com/inward/record.url?scp=0027724044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027724044&partnerID=8YFLogxK
U2 - 10.1097/00000441-199312000-00009
DO - 10.1097/00000441-199312000-00009
M3 - Article
C2 - 8266983
AN - SCOPUS:0027724044
SN - 0002-9629
VL - 306
SP - 398
EP - 406
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 6
ER -