Sorting out Toll Signals

Katherine A. Fitzgerald; Zhijian J. Chen

doi:10.1016/j.cell.2006.05.014

Sorting out Toll Signals

Katherine A. Fitzgerald, Zhijian J. Chen

Research output: Contribution to journal › Short survey › peer-review

84 Scopus citations

Abstract

Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

Original language	English (US)
Pages (from-to)	834-836
Number of pages	3
Journal	Cell
Volume	125
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2006.05.014
State	Published - Jun 2 2006

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2006.05.014

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title = "Sorting out Toll Signals",

abstract = "Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.",

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AU - Fitzgerald, Katherine A.

AU - Chen, Zhijian J.

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AB - Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

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JO - Cell

JF - Cell

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ER -

Sorting out Toll Signals

Abstract

ASJC Scopus subject areas

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