Sorting out Toll Signals

Katherine A. Fitzgerald, Zhijian J. Chen

Research output: Contribution to journalShort surveypeer-review

84 Scopus citations


Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.

Original languageEnglish (US)
Pages (from-to)834-836
Number of pages3
Issue number5
StatePublished - Jun 2 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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