Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Iris Bea L. Ramiro; Walden E. Bjørn-Yoshimoto; Julita S. Imperial; Joanna Gajewiak; Paula Florez Salcedo; Maren Watkins; Dylan Taylor; William Resager; Beatrix Ueberheide; Hans Brauner-Osborne; Frank G. Whitby; Christopher P. Hill; Laurent F. Martin; Amol Patwardhan; Gisela P. Concepcion; Baldomero M. Olivera; Helena Safavi-Hemami

doi:10.1126/sciadv.abk1410

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

Iris Bea L. Ramiro, Walden E. Bjørn-Yoshimoto, Julita S. Imperial, Joanna Gajewiak, Paula Florez Salcedo, Maren Watkins, Dylan Taylor, William Resager, Beatrix Ueberheide, Hans Brauner-Osborne, Frank G. Whitby, Christopher P. Hill, Laurent F. Martin, Amol Patwardhan, Gisela P. Concepcion, Baldomero M. Olivera, Helena Safavi-Hemami

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.

Original language	English (US)
Article number	eabk1410
Journal	Science Advances
Volume	8
Issue number	12
DOIs	https://doi.org/10.1126/sciadv.abk1410
State	Published - Mar 2022
Externally published	Yes

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Ramiro, I. B. L., Bjørn-Yoshimoto, W. E., Imperial, J. S., Gajewiak, J., Florez Salcedo, P., Watkins, M., Taylor, D., Resager, W., Ueberheide, B., Brauner-Osborne, H., Whitby, F. G., Hill, C. P., Martin, L. F., Patwardhan, A., Concepcion, G. P., Olivera, B. M., & Safavi-Hemami, H. (2022). Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Science Advances, 8(12), Article eabk1410. https://doi.org/10.1126/sciadv.abk1410

Ramiro, IBL, Bjørn-Yoshimoto, WE, Imperial, JS, Gajewiak, J, Florez Salcedo, P, Watkins, M, Taylor, D, Resager, W, Ueberheide, B, Brauner-Osborne, H, Whitby, FG, Hill, CP, Martin, LF, Patwardhan, A, Concepcion, GP, Olivera, BM & Safavi-Hemami, H 2022, 'Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads', Science Advances, vol. 8, no. 12, eabk1410. https://doi.org/10.1126/sciadv.abk1410

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AU - Florez Salcedo, Paula

AU - Watkins, Maren

AU - Taylor, Dylan

AU - Resager, William

AU - Ueberheide, Beatrix

AU - Brauner-Osborne, Hans

AU - Whitby, Frank G.

AU - Hill, Christopher P.

AU - Martin, Laurent F.

AU - Patwardhan, Amol

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Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

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