TY - JOUR
T1 - Soft Tissue Special Issue
T2 - Adamantinoma-Like Ewing Sarcoma of the Head and Neck: A Practical Review of a Challenging Emerging Entity
AU - Rooper, Lisa M.
AU - Bishop, Justin A.
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma that is defined by complex epithelial differentiation, including expression of cytokeratin and p40 and frequent keratin pearl formation. In recent years, ALES has been increasingly recognized in the head and neck, where it can mimic a wide range of small round blue cell tumors and basaloid carcinomas. However, there has been persistent controversy regarding whether ALES is best classified and managed as a sarcoma or carcinoma. This review summarizes the characteristic clinical, pathologic, immunophenotypic, and molecular features of ALES with an emphasis on differential diagnosis and tumor classification.
AB - Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma that is defined by complex epithelial differentiation, including expression of cytokeratin and p40 and frequent keratin pearl formation. In recent years, ALES has been increasingly recognized in the head and neck, where it can mimic a wide range of small round blue cell tumors and basaloid carcinomas. However, there has been persistent controversy regarding whether ALES is best classified and managed as a sarcoma or carcinoma. This review summarizes the characteristic clinical, pathologic, immunophenotypic, and molecular features of ALES with an emphasis on differential diagnosis and tumor classification.
KW - Adamantinoma-like Ewing sarcoma
KW - Complex epithelial differentiation
KW - EWSR1
KW - Ewing sarcoma
KW - FLI1
UR - http://www.scopus.com/inward/record.url?scp=85078254534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078254534&partnerID=8YFLogxK
U2 - 10.1007/s12105-019-01098-y
DO - 10.1007/s12105-019-01098-y
M3 - Review article
C2 - 31950471
AN - SCOPUS:85078254534
SN - 1936-055X
VL - 14
SP - 59
EP - 69
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 1
ER -