Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events

Julie R. Brahmer; Hamzah Abu-Sbeih; Paolo Antonio Ascierto; Jill Brufsky; Laura C. Cappelli; Frank B. Cortazar; David E. Gerber; Lamya Hamad; Eric Hansen; Douglas B. Johnson; Mario E. Lacouture; Gregory A. Masters; Jarushka Naidoo; Michele Nanni; Miguel Angel Perales; Igor Puzanov; Bianca D. Santomasso; Satish P. Shanbhag; Rajeev Sharma; Dimitra Skondra; Jeffrey A. Sosman; Michelle Turner; Marc S. Ernstoff

doi:10.1136/jitc-2021-002435

Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events

Julie R. Brahmer, Hamzah Abu-Sbeih, Paolo Antonio Ascierto, Jill Brufsky, Laura C. Cappelli, Frank B. Cortazar, David E. Gerber, Lamya Hamad, Eric Hansen, Douglas B. Johnson, Mario E. Lacouture, Gregory A. Masters, Jarushka Naidoo, Michele Nanni, Miguel Angel Perales, Igor Puzanov, Bianca D. Santomasso, Satish P. Shanbhag, Rajeev Sharma, Dimitra SkondraJeffrey A. Sosman, Michelle Turner, Marc S. Ernstoff

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300 Scopus citations

Abstract

Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune-related adverse events (irAEs). There is a need for clear, effective guidelines for the management of irAEs during ICI treatment, motivating the Society for Immunotherapy of Cancer (SITC) to convene an expert panel to develop a clinical practice guideline. The panel discussed the recognition and management of single and combination ICI irAEs and ultimately developed evidence- and consensus-based recommendations to assist medical professionals in clinical decision-making and to improve outcomes for patients.

Original language	English (US)
Article number	e002435
Journal	Journal for ImmunoTherapy of Cancer
Volume	9
Issue number	6
DOIs	https://doi.org/10.1136/jitc-2021-002435
State	Published - Jun 25 2021

Keywords

Antineoplastic protocols
Guidelines as topic
Immunotherapy

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.1136/jitc-2021-002435

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Brahmer, J. R., Abu-Sbeih, H., Ascierto, P. A., Brufsky, J., Cappelli, L. C., Cortazar, F. B., Gerber, D. E., Hamad, L., Hansen, E., Johnson, D. B., Lacouture, M. E., Masters, G. A., Naidoo, J., Nanni, M., Perales, M. A., Puzanov, I., Santomasso, B. D., Shanbhag, S. P., Sharma, R., ... Ernstoff, M. S. (2021). Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events. Journal for ImmunoTherapy of Cancer, 9(6), Article e002435. https://doi.org/10.1136/jitc-2021-002435

Brahmer, JR, Abu-Sbeih, H, Ascierto, PA, Brufsky, J, Cappelli, LC, Cortazar, FB, Gerber, DE, Hamad, L, Hansen, E, Johnson, DB, Lacouture, ME, Masters, GA, Naidoo, J, Nanni, M, Perales, MA, Puzanov, I, Santomasso, BD, Shanbhag, SP, Sharma, R, Skondra, D, Sosman, JA, Turner, M & Ernstoff, MS 2021, 'Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events', Journal for ImmunoTherapy of Cancer, vol. 9, no. 6, e002435. https://doi.org/10.1136/jitc-2021-002435

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abstract = "Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune-related adverse events (irAEs). There is a need for clear, effective guidelines for the management of irAEs during ICI treatment, motivating the Society for Immunotherapy of Cancer (SITC) to convene an expert panel to develop a clinical practice guideline. The panel discussed the recognition and management of single and combination ICI irAEs and ultimately developed evidence- and consensus-based recommendations to assist medical professionals in clinical decision-making and to improve outcomes for patients.",

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AU - Ascierto, Paolo Antonio

AU - Brufsky, Jill

AU - Cappelli, Laura C.

AU - Cortazar, Frank B.

AU - Gerber, David E.

AU - Hamad, Lamya

AU - Hansen, Eric

AU - Johnson, Douglas B.

AU - Lacouture, Mario E.

AU - Masters, Gregory A.

AU - Naidoo, Jarushka

AU - Nanni, Michele

AU - Perales, Miguel Angel

AU - Puzanov, Igor

AU - Santomasso, Bianca D.

AU - Shanbhag, Satish P.

AU - Sharma, Rajeev

AU - Skondra, Dimitra

AU - Sosman, Jeffrey A.

AU - Turner, Michelle

AU - Ernstoff, Marc S.

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AB - Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune-related adverse events (irAEs). There is a need for clear, effective guidelines for the management of irAEs during ICI treatment, motivating the Society for Immunotherapy of Cancer (SITC) to convene an expert panel to develop a clinical practice guideline. The panel discussed the recognition and management of single and combination ICI irAEs and ultimately developed evidence- and consensus-based recommendations to assist medical professionals in clinical decision-making and to improve outcomes for patients.

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Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events

Abstract

Keywords

ASJC Scopus subject areas

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