SNAREs

Jose Rizo-Rey

doi:10.1016/B978-008045046-9.01357-7

SNAREs

Jose Rizo-Rey

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are central components of a conserved protein machinery that governs most types of intracellular membrane traffic by virtue of their ability to form tight SNARE complexes that bring two membranes together. Synaptobrevin 2, syntaxin 1, and synaptosomal associated protein of 25kDa (SNAP-25), the neuronal SNAREs that control neurotransmitter release, share common features with other members of the SNARE family that underlie a conserved membrane fusion mechanism. In addition, the neuronal SNAREs have unique properties that enable interactions with specialized components of the neurotransmitter-release machinery and contribute to the exquisite temporal and spatial regulation of Ca²⁺-triggered synaptic vesicle exocytosis.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	11-19
Number of pages	9
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01357-7
State	Published - Jan 1 2009

Keywords

Complexin
Membrane fusion
Munc18-1
NSF
Neurotransmitter release
SNAP-25
SNAPs
SNAREs
Synaptic transmission
Synaptic vesicle exocytosis
Synaptobrevin-VAMP
Synaptotagmin
Syntaxin

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-008045046-9.01357-7

Cite this

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title = "SNAREs",

abstract = "Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are central components of a conserved protein machinery that governs most types of intracellular membrane traffic by virtue of their ability to form tight SNARE complexes that bring two membranes together. Synaptobrevin 2, syntaxin 1, and synaptosomal associated protein of 25kDa (SNAP-25), the neuronal SNAREs that control neurotransmitter release, share common features with other members of the SNARE family that underlie a conserved membrane fusion mechanism. In addition, the neuronal SNAREs have unique properties that enable interactions with specialized components of the neurotransmitter-release machinery and contribute to the exquisite temporal and spatial regulation of Ca2+-triggered synaptic vesicle exocytosis.",

keywords = "Complexin, Membrane fusion, Munc18-1, NSF, Neurotransmitter release, SNAP-25, SNAPs, SNAREs, Synaptic transmission, Synaptic vesicle exocytosis, Synaptobrevin-VAMP, Synaptotagmin, Syntaxin",

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year = "2009",

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doi = "10.1016/B978-008045046-9.01357-7",

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AB - Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are central components of a conserved protein machinery that governs most types of intracellular membrane traffic by virtue of their ability to form tight SNARE complexes that bring two membranes together. Synaptobrevin 2, syntaxin 1, and synaptosomal associated protein of 25kDa (SNAP-25), the neuronal SNAREs that control neurotransmitter release, share common features with other members of the SNARE family that underlie a conserved membrane fusion mechanism. In addition, the neuronal SNAREs have unique properties that enable interactions with specialized components of the neurotransmitter-release machinery and contribute to the exquisite temporal and spatial regulation of Ca2+-triggered synaptic vesicle exocytosis.

KW - Complexin

KW - Membrane fusion

KW - Munc18-1

KW - NSF

KW - Neurotransmitter release

KW - SNAP-25

KW - SNAPs

KW - SNAREs

KW - Synaptic transmission

KW - Synaptic vesicle exocytosis

KW - Synaptobrevin-VAMP

KW - Synaptotagmin

KW - Syntaxin

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SN - 9780080450469

SP - 11

EP - 19

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

SNAREs

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Keywords

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