SNARE-mediated membrane fusion in autophagy

Yongyao Wang, Linsen Li, Chen Hou, Ying Lai, Jiangang Long, Jiankang Liu, Qing Zhong, Jiajie Diao

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalSeminars in Cell and Developmental Biology
StatePublished - Dec 1 2016


  • Autophagy
  • Membrane fusion

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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