Small cell lung cancers made from scratch

Adi F. Gazdar; John D. Minna

doi:10.1084/jem.20182216

Small cell lung cancers made from scratch

Adi F. Gazdar, John D. Minna

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.

Original language	English (US)
Pages (from-to)	476-478
Number of pages	3
Journal	Journal of Experimental Medicine
Volume	216
Issue number	3
DOIs	https://doi.org/10.1084/jem.20182216
State	Published - Mar 1 2019

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1084/jem.20182216

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title = "Small cell lung cancers made from scratch",

abstract = "In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.",

author = "Gazdar, {Adi F.} and Minna, {John D.}",

note = "Funding Information: This work was supported by grants from the National Cancer Institute (P50 CA70907, U24CA213274, and U01 CA213338). Publisher Copyright: {\textcopyright} 2019 Gazdar and Minna. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).",

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AU - Gazdar, Adi F.

AU - Minna, John D.

N1 - Funding Information: This work was supported by grants from the National Cancer Institute (P50 CA70907, U24CA213274, and U01 CA213338). Publisher Copyright: © 2019 Gazdar and Minna. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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N2 - In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.

AB - In this issue of JEM, Chen et al. (https://doi.org/10.1084/jem.20181155) describe a new approach for the transformation of human pluripotent embryonic stem cells (hESCs) into neuroendocrine (NE) tumors of the lung closely resembling human small cell lung cancer (SCLC). Another recent study uses a different method to transform fully differentiated normal human cells into high-grade NE tumors (Park et al. 2018. Science. https://doi.org/10.1126/science.aat5749). These approaches and their models provide important new resources for developing diagnostic, preventative, and therapeutic approaches for high-grade NE tumors.

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Small cell lung cancers made from scratch

Abstract

ASJC Scopus subject areas

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