Sleep, feeding, and neuropeptides: Roles of orexins and orexin receptors

Michihiro Mieda, Masashi Yanagisawa

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in sleep/wake regulation. In addition, the orexin system may link energy homeostasis to the regulation of sleep/wake cycles.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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