Sleep and Epilepsy

Wei K. Liu; Sanjeev Kothare; Sejal Jain

doi:10.1016/j.spen.2023.101087

Sleep and Epilepsy

Wei K. Liu, Sanjeev Kothare, Sejal Jain

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The relationship between sleep and epilepsy is both intimate and bidirectional. The molecular mechanisms which control circadian rhythm and the sleep/wake cycle are dysregulated in epileptogenic tissue and are themselves effected by molecular pathways for epilepsy. Sleep affects the frequency of interictal epileptiform discharges and recent research has raised new questions regarding the impact of discharges on sleep function and cognition. Epileptiform discharges themselves affect sleep architecture and increase the risk of sleep disorders. Several sleep-related epilepsy syndromes have undergone changes in their classification which highlights their intimate relationship to sleep and novel screening tools have been developed to help clinicians better differentiate epileptic seizures from sleep-related paroxysmal events. Improving sleep and addressing sleep disorders has been associated with improved seizure control and increased well-being in people with epilepsy. These interactions are discussed in detail in this review.

Original language	English (US)
Article number	101087
Journal	Seminars in Pediatric Neurology
Volume	48
DOIs	https://doi.org/10.1016/j.spen.2023.101087
State	Published - Dec 2023
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

Access to Document

10.1016/j.spen.2023.101087

Cite this

@article{cae4e52e69f2446589f18d172af2b50e,

title = "Sleep and Epilepsy",

abstract = "The relationship between sleep and epilepsy is both intimate and bidirectional. The molecular mechanisms which control circadian rhythm and the sleep/wake cycle are dysregulated in epileptogenic tissue and are themselves effected by molecular pathways for epilepsy. Sleep affects the frequency of interictal epileptiform discharges and recent research has raised new questions regarding the impact of discharges on sleep function and cognition. Epileptiform discharges themselves affect sleep architecture and increase the risk of sleep disorders. Several sleep-related epilepsy syndromes have undergone changes in their classification which highlights their intimate relationship to sleep and novel screening tools have been developed to help clinicians better differentiate epileptic seizures from sleep-related paroxysmal events. Improving sleep and addressing sleep disorders has been associated with improved seizure control and increased well-being in people with epilepsy. These interactions are discussed in detail in this review.",

author = "Liu, {Wei K.} and Sanjeev Kothare and Sejal Jain",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2023",

month = dec,

doi = "10.1016/j.spen.2023.101087",

language = "English (US)",

volume = "48",

journal = "Seminars in Pediatric Neurology",

issn = "1071-9091",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Sleep and Epilepsy

AU - Liu, Wei K.

AU - Kothare, Sanjeev

AU - Jain, Sejal

PY - 2023/12

Y1 - 2023/12

N2 - The relationship between sleep and epilepsy is both intimate and bidirectional. The molecular mechanisms which control circadian rhythm and the sleep/wake cycle are dysregulated in epileptogenic tissue and are themselves effected by molecular pathways for epilepsy. Sleep affects the frequency of interictal epileptiform discharges and recent research has raised new questions regarding the impact of discharges on sleep function and cognition. Epileptiform discharges themselves affect sleep architecture and increase the risk of sleep disorders. Several sleep-related epilepsy syndromes have undergone changes in their classification which highlights their intimate relationship to sleep and novel screening tools have been developed to help clinicians better differentiate epileptic seizures from sleep-related paroxysmal events. Improving sleep and addressing sleep disorders has been associated with improved seizure control and increased well-being in people with epilepsy. These interactions are discussed in detail in this review.

AB - The relationship between sleep and epilepsy is both intimate and bidirectional. The molecular mechanisms which control circadian rhythm and the sleep/wake cycle are dysregulated in epileptogenic tissue and are themselves effected by molecular pathways for epilepsy. Sleep affects the frequency of interictal epileptiform discharges and recent research has raised new questions regarding the impact of discharges on sleep function and cognition. Epileptiform discharges themselves affect sleep architecture and increase the risk of sleep disorders. Several sleep-related epilepsy syndromes have undergone changes in their classification which highlights their intimate relationship to sleep and novel screening tools have been developed to help clinicians better differentiate epileptic seizures from sleep-related paroxysmal events. Improving sleep and addressing sleep disorders has been associated with improved seizure control and increased well-being in people with epilepsy. These interactions are discussed in detail in this review.

UR - http://www.scopus.com/inward/record.url?scp=85173838155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85173838155&partnerID=8YFLogxK

U2 - 10.1016/j.spen.2023.101087

DO - 10.1016/j.spen.2023.101087

M3 - Article

C2 - 38065633

AN - SCOPUS:85173838155

SN - 1071-9091

VL - 48

JO - Seminars in Pediatric Neurology

JF - Seminars in Pediatric Neurology

M1 - 101087

ER -

Sleep and Epilepsy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this