Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts

Ilja L. Kruglikov, Zhuzhen Zhang, Philipp E. Scherer

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Emerging data connects the aging process in dermal fibroblasts with metabolic reprogramming, provided by enhanced fatty acid oxidation and reduced glycolysis. This switch may be caused by a significant expansion of the dermal white adipose tissue (dWAT) layer in aged, hair-covered skin. Dermal adipocytes cycle through de-differentiation and re-differentiation. As a result, there is a strongly enhanced release of free fatty acids into the extracellular space during the de-differentiation of dermal adipocytes in the catagen phase of the hair follicle cycle. Both caveolin-1 and adiponectin are critical factors influencing these processes. Controlling the expression levels of these two factors also offers the ability to manipulate the metabolic preferences of the different cell types within the microenvironment of the skin, including dermal fibroblasts. Differential expression of adiponectin and caveolin-1 in the various cell types may also be responsible for the cellular metabolic heterogeneity within the cells of the skin.

Original languageEnglish (US)
Article number2100207
Issue number1
StatePublished - Jan 2022


  • CD36
  • adiponectin
  • aging
  • caveolin
  • dermal adipose tissue
  • glycolysis
  • oxidative phosphorylation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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