Sinonasal Small Round Blue Cell Tumors: An Immunohistochemical Approach

Lisa M. Rooper, Justin A. Bishop

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Although clinical history and morphologic appearance should be the initial considerations when evaluating small round blue cell tumors of the sinonasal tract, the final diagnosis often hinges on immunohistochemical findings. Unfortunately, interpretation of stains in these tumors is fraught with numerous pitfalls and limitations. This article presents an approach to sinonasal small round blue cell tumors based on four common immunohistochemical patterns: cytokeratin positivity, squamous marker positivity, neuroendocrine marker positivity, and cytokeratin negativity.

Original languageEnglish (US)
Pages (from-to)103-123
Number of pages21
JournalSurgical Pathology Clinics
Issue number1
StatePublished - Mar 1 2017


  • Cytokeratin
  • Immunohistochemistry
  • Neuroendocrine differentiation
  • Sinonasal tumors
  • Small round blue cell tumors
  • Squamous differentiation

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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