Single-shot RARE with Dixon: Application to robust abdominal imaging with uniform fat and water separation at 3T

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Purpose: To develop a true single shot turbo spin echo (SShTSE) acquisition with Dixon for robust T2-weighted abdominal imaging with uniform fat and water separation at 3T. Methods: The in-phase (IP) and out-of-phase (OP) echoes for Dixon processing were acquired in the same repetition time of a SShTSE using partial echoes. A phase-preserved bi-directional homodyne reconstruction was developed to compensate the partial echo and the partial phase encoding of SShTSE. With IRB approval, the SShTSE-Dixon was compared against standard SShTSE, without and with fat suppression using spectral adiabatic inversion recovery (SPAIR) in 5 healthy volunteers and 5 patients. The SNR and contrast ratio (CR) of spleen to liver were compared among different acquisitions. Results: The bi-directional homodyne reconstruction successfully minimized ringing artifacts because of partial acquisitions. SShTSE-Dixon achieved uniform fat suppression compared to SShTSE-SPAIR with fat suppression failures of 1/10 versus 10/10 in the axial plane and 0/5 versus 5/5 in the coronal plane, respectively. The SNRs of the liver (12.2 ± 4.9 vs. 11.7 ± 5.2; P =.76) and spleen (25.9 ± 11.6 vs. 23.7 ± 9.7; P =.14) were equivalent between fat-suppressed images (SShTSE-Dixon water-only and SShTSE-SPAIR). The SNRs of liver (14.4 ± 5.7 vs. 13.4 ± 5.0; P =.60) and spleen (26.5 ± 10.1 vs. 25.7 ± 8.5; P =.56) were equivalent between non-fat-suppressed images (SShTSE-Dixon IP and SShTSE). The CRs of spleen to liver were also similar between fat-suppressed images (2.6 ± 0.4 vs. 2.5 ± 0.5; P =.92) and non-fat-suppressed images (2.3 ± 0.6 vs. 2.2 ± 0.4; P =.84). Conclusion: SShTSE-Dixon generates robust abdominal T2-weighted images at 3T with and without uniform fat suppression, along with perfectly co-registered fat-only images in a single acquisition.

Original languageEnglish (US)
Pages (from-to)1463-1471
Number of pages9
JournalMagnetic resonance in medicine
Issue number3
StatePublished - Sep 2021


  • Dixon
  • RARE
  • SShTSE
  • fat suppression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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