Single-dose antimicrobial prophylaxis at abdominal hysterectomy: Cefamandole vs. cefotaxime

D. L. Hemsell, J. N. Martin, J. G. Pastorek, B. J. Nobles, P. G. Hemsell, N. Helman, P. Blake, M. K. Lindsey, S. K. Nicaud

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1 Scopus citations


Two hundred twenty-three women were given a single, 1-g, intravenous dose of cefamandole or cefotaxime at elective abdominal hysterectomy in a multicenter, prospective, randomized, blind clinical trial of efficacy and safety. The demographic, surgical, efficacy and safety variables were statistically similar. Prior to discharge from the hospital, 12 women (5.3%) developed major postoperative pelvic infections that required parenteral antimicrobial therapy; no wound infections occurred. There was no correlation between a depressed antimicrobial concentration in serum and/or tissue and the development of significant postoperative infection. An expanded spectrum of antibacterial activity and a longer serum half-life did not improve clinical efficacy, and single-dose intravenous cephalosporin prophylaxis before abdominal hysterectomy was associated with a low incidence of pelvic infection.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number12
StatePublished - Dec 1 1988

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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