Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

Hoi Hin Kwok; Huiyu Li; Jiashuang Yang; Junyang Deng; Nerissa Chui Mei Lee; Timmy Wing Kuk Au; Alva Ko Yung Sit; Michael Kuan Yew Hsin; Stephanie Kwai Yee Ma; Lydia Wai Ting Cheung; Luc Girard; Junya Fujimoto; Ignacio Ivan Wistuba; Boning Gao; John Dorrance Minna; David Chi Leung Lam

doi:10.1002/cac2.12449

Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

Hoi Hin Kwok, Huiyu Li, Jiashuang Yang, Junyang Deng, Nerissa Chui Mei Lee, Timmy Wing Kuk Au, Alva Ko Yung Sit, Michael Kuan Yew Hsin, Stephanie Kwai Yee Ma, Lydia Wai Ting Cheung, Luc Girard, Junya Fujimoto, Ignacio Ivan Wistuba, Boning Gao, John Dorrance Minna, David Chi Leung Lam

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Original language	English (US)
Pages (from-to)	951-955
Number of pages	5
Journal	Cancer Communications
Volume	43
Issue number	8
DOIs	https://doi.org/10.1002/cac2.12449
State	Published - Aug 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/cac2.12449

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Kwok, H. H., Li, H., Yang, J., Deng, J., Lee, N. C. M., Au, T. W. K., Sit, A. K. Y., Hsin, M. K. Y., Ma, S. K. Y., Cheung, L. W. T., Girard, L., Fujimoto, J., Wistuba, I. I., Gao, B., Minna, J. D., & Lam, D. C. L. (2023). Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma. Cancer Communications, 43(8), 951-955. https://doi.org/10.1002/cac2.12449

Kwok, HH, Li, H, Yang, J, Deng, J, Lee, NCM, Au, TWK, Sit, AKY, Hsin, MKY, Ma, SKY, Cheung, LWT, Girard, L, Fujimoto, J, Wistuba, II, Gao, B , Minna, JD & Lam, DCL 2023, 'Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma', Cancer Communications, vol. 43, no. 8, pp. 951-955. https://doi.org/10.1002/cac2.12449

@article{d955971f7500481f9c583bcdea35303d,

title = "Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma",

author = "Kwok, {Hoi Hin} and Huiyu Li and Jiashuang Yang and Junyang Deng and Lee, {Nerissa Chui Mei} and Au, {Timmy Wing Kuk} and Sit, {Alva Ko Yung} and Hsin, {Michael Kuan Yew} and Ma, {Stephanie Kwai Yee} and Cheung, {Lydia Wai Ting} and Luc Girard and Junya Fujimoto and Wistuba, {Ignacio Ivan} and Boning Gao and Minna, {John Dorrance} and Lam, {David Chi Leung}",

note = "Funding Information: The research work described in this report was supported by the Lee and the Ho Families Respiratory Research Fund (research donation to DCL). National Natural Science Foundation of China (Grant# 82022078 to LWTC). United States National Cancer Institute Lung Cancer Specialized Program in Research Excellence (SPORE) P50 (CA070907 to JDM). Funding Information: The research work described in this report was supported by the Lee and the Ho Families Respiratory Research Fund (research donation to DCL). National Natural Science Foundation of China (Grant# 82022078 to LWTC). United States National Cancer Institute Lung Cancer Specialized Program in Research Excellence (SPORE) P50 (CA070907 to JDM). Not applicable.",

year = "2023",

month = aug,

doi = "10.1002/cac2.12449",

language = "English (US)",

volume = "43",

pages = "951--955",

journal = "Cancer Communications",

issn = "1000-467X",

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T1 - Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

AU - Kwok, Hoi Hin

AU - Li, Huiyu

AU - Yang, Jiashuang

AU - Deng, Junyang

AU - Lee, Nerissa Chui Mei

AU - Au, Timmy Wing Kuk

AU - Sit, Alva Ko Yung

AU - Hsin, Michael Kuan Yew

AU - Ma, Stephanie Kwai Yee

AU - Cheung, Lydia Wai Ting

AU - Girard, Luc

AU - Fujimoto, Junya

AU - Wistuba, Ignacio Ivan

AU - Gao, Boning

AU - Minna, John Dorrance

AU - Lam, David Chi Leung

N1 - Funding Information: The research work described in this report was supported by the Lee and the Ho Families Respiratory Research Fund (research donation to DCL). National Natural Science Foundation of China (Grant# 82022078 to LWTC). United States National Cancer Institute Lung Cancer Specialized Program in Research Excellence (SPORE) P50 (CA070907 to JDM). Funding Information: The research work described in this report was supported by the Lee and the Ho Families Respiratory Research Fund (research donation to DCL). National Natural Science Foundation of China (Grant# 82022078 to LWTC). United States National Cancer Institute Lung Cancer Specialized Program in Research Excellence (SPORE) P50 (CA070907 to JDM). Not applicable.

PY - 2023/8

Y1 - 2023/8

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U2 - 10.1002/cac2.12449

DO - 10.1002/cac2.12449

M3 - Letter

C2 - 37272226

AN - SCOPUS:85161438790

SN - 1000-467X

VL - 43

SP - 951

EP - 955

JO - Cancer Communications

JF - Cancer Communications

IS - 8

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Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma

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