Simultaneous “In Series” Hemodialysis and Hemoperfusion in the Management of Valproic Acid Overdose

J. E. Tank, B. F. Palmer

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


There is little published experience with the extracorporeal treatment of valproic acid overdose, although the pharmacokinetic properties of valproic acid suggest a potential role for hemodialysis and/or hemoperfusion. At therapeutic concentrations valproic acid is highly protein bound, but at the higher concentrations seen in the overdose setting binding sites become saturated and free valproic acid should be subject to removal by hemodialysis. We report the case of a patient with serious toxicity secondary to valproic acid overdose who was successfully treated with a combination of hemodialysis and hemoperfusion. With this treatment the half-life of valproic acid was reduced from a predialysis level of 13 hours to 1.7 hours, with rapid lowering of valproic acid levels and dramatic clinical improvement. Based on our experience in this patient and a review of previously reported cases, hemodialysis should be considered in the treatment of valproic acid overdose.

Original languageEnglish (US)
Pages (from-to)341-344
Number of pages4
JournalAmerican Journal of Kidney Diseases
Issue number2
StatePublished - 1993


  • Valproic acid
  • hemodialysis
  • hemoperfusion
  • overdose

ASJC Scopus subject areas

  • Nephrology


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