Signaling pathways of cbl-b and its role in peripheral t cell tolerance

K. Venuprasad

doi:10.1007/978-94-007-6211-4_8

Signaling pathways of cbl-b and its role in peripheral t cell tolerance

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The E3 ubiquitin ligase Cbl-b acts as a key regulator of T cell activation and peripheral tolerance. Cbl-b deficiency uncouples the requirement of CD28 costimulation for T cell activation and exhibits resistance to T cell anergy and tolerance. Cbl-bmice are highly susceptible to autoimmune diseases. Conversely, they mount a robust antitumor response resulting in spontaneous tumor rejection. Therefore, modulation of Cbl-b might provide a unique opportunity for immunotherapeutic strategies for inflammatory disorders, including autoimmunity and cancer.

Original language	English (US)
Title of host publication	Trends in Stem Cell Proliferation and Cancer Research
Publisher	Springer Netherlands
Pages	195-203
Number of pages	9
ISBN (Electronic)	9789400762114
ISBN (Print)	9789400762107
DOIs	https://doi.org/10.1007/978-94-007-6211-4_8
State	Published - Jan 1 2013
Externally published	Yes

Keywords

Anergy
Cbl-b
Regulatory T cells
Tolerance
Ubiquitination

ASJC Scopus subject areas

General Medicine

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10.1007/978-94-007-6211-4_8

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AB - The E3 ubiquitin ligase Cbl-b acts as a key regulator of T cell activation and peripheral tolerance. Cbl-b deficiency uncouples the requirement of CD28 costimulation for T cell activation and exhibits resistance to T cell anergy and tolerance. Cbl-bmice are highly susceptible to autoimmune diseases. Conversely, they mount a robust antitumor response resulting in spontaneous tumor rejection. Therefore, modulation of Cbl-b might provide a unique opportunity for immunotherapeutic strategies for inflammatory disorders, including autoimmunity and cancer.

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KW - Ubiquitination

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ER -

Signaling pathways of cbl-b and its role in peripheral t cell tolerance

Abstract

Keywords

ASJC Scopus subject areas

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