Signaling pathways of cbl-b and its role in peripheral t cell tolerance

Research output: Chapter in Book/Report/Conference proceedingChapter


The E3 ubiquitin ligase Cbl-b acts as a key regulator of T cell activation and peripheral tolerance. Cbl-b deficiency uncouples the requirement of CD28 costimulation for T cell activation and exhibits resistance to T cell anergy and tolerance. Cbl-bmice are highly susceptible to autoimmune diseases. Conversely, they mount a robust antitumor response resulting in spontaneous tumor rejection. Therefore, modulation of Cbl-b might provide a unique opportunity for immunotherapeutic strategies for inflammatory disorders, including autoimmunity and cancer.

Original languageEnglish (US)
Title of host publicationTrends in Stem Cell Proliferation and Cancer Research
PublisherSpringer Netherlands
Number of pages9
ISBN (Electronic)9789400762114
ISBN (Print)9789400762107
StatePublished - Jan 1 2013
Externally publishedYes


  • Anergy
  • Cbl-b
  • Regulatory T cells
  • Tolerance
  • Ubiquitination

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Signaling pathways of cbl-b and its role in peripheral t cell tolerance'. Together they form a unique fingerprint.

Cite this