Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Vladimir Zhemkov; Jen Liou; Ilya Bezprozvanny

doi:10.1177/25152564211026505

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Vladimir Zhemkov, Jen Liou, Ilya Bezprozvanny

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.

Original language	English (US)
Journal	Contact
Volume	4
DOIs	https://doi.org/10.1177/25152564211026505
State	Published - Jan 1 2021

Keywords

cholesterol
endoplasmic reticulum
lipid microdomains
membrane contact sites
mitochondria-associated membranes
sigma-1 receptor

ASJC Scopus subject areas

Cell Biology
Physiology

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10.1177/25152564211026505

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title = "Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites",

abstract = "Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.",

keywords = "cholesterol, endoplasmic reticulum, lipid microdomains, membrane contact sites, mitochondria-associated membranes, sigma-1 receptor",

author = "Vladimir Zhemkov and Jen Liou and Ilya Bezprozvanny",

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T1 - Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

AU - Zhemkov, Vladimir

AU - Liou, Jen

AU - Bezprozvanny, Ilya

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.

AB - Recent studies indicated potential importance of membrane contact sites (MCS) between the endoplasmic reticulum (ER) and other cellular organelles. These MCS have unique protein and lipid composition and serve as hubs for inter-organelle communication and signaling. Despite extensive investigation of MCS protein composition and functional roles, little is known about the process of MCS formation. In this perspective, we propose a hypothesis that MCS are formed not as a result of random interactions between membranes of ER and other organelles but on the basis of pre-existing cholesterol-enriched ER microdomains.

KW - cholesterol

KW - endoplasmic reticulum

KW - lipid microdomains

KW - membrane contact sites

KW - mitochondria-associated membranes

KW - sigma-1 receptor

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ER -

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites

Abstract

Keywords

ASJC Scopus subject areas

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