@inbook{b2373b27ac8f4c42bd7063e977bc6a2c,
title = "Sigma-1 Receptor and neuronal excitability",
abstract = "The sigma-1 receptor (Sig-1R), via interaction with various proteins, including voltage-gated and ligand-gated ion channels (VGICs and LGICs), is involved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the transmission of information within brain circuits. This versatility may also explain why the Sig-1R is associated to numerous diseases at both peripheral and central levels. To date, how the Sig-1R chooses its targets and how the combinations of target modulations alter overall neuronal excitability is one of the challenges in the field of Sig-1R-dependent regulation of neuronal activity. Here, we will describe and discuss the latest findings on Sig-1R-dependent modulation of VGICs and LGICs, and provide hypotheses that may explain the diverse excitability outcomes that have been reported so far.",
keywords = "AMPA receptor, Auxiliary subunit, Calcium channels, Chaperone protein, Intrinsic excitability, NMDA receptor, Potassium channels, Sigma-1 receptor, Sodium channels, Voltage-gated ion channels",
author = "Sa{\"i}d Kourrich",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing AG 2017.",
year = "2017",
doi = "10.1007/164_2017_8",
language = "English (US)",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer New York LLC",
pages = "109--130",
booktitle = "Handbook of Experimental Pharmacology",
}