Sickle cell anemia

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Sickle cell disease is a member of a family of genetic disorders involving abnormal hemoglobin. The most prevalent hemoglobinopathy is sickle cell anemia resulting from the homozygous SS genotype. Pregnancy is a serious burden to women with sickle hemoglobinopathies, especially those with hemoglobin SS disease. Pregnancy usually results in an increased frequency of sickle cell crises. Infections and pulmonary complications are common. Maternal mortality has decreased dramatically over the years because of improvements in medical care, but remains high.

Original languageEnglish (US)
Title of host publicationQueenan's Management of High-Risk Pregnancy
Subtitle of host publicationAn Evidence-Based Approach: Sixth Edition
Number of pages5
ISBN (Print)9780470655764
StatePublished - Jan 4 2012


  • Hemoglobin S/β-thalassemia disease
  • Hemoglobin SC disease
  • Hemolysis of defective RBCs
  • Hemolysis, viscosity, and VOC
  • Maternal disease
  • Pregnancy, burden to women with sickle hemoglobinopathies
  • Red blood cells with hemoglobin S undergoing sickling
  • Sickle cell anemia, and homozygous SS genotype
  • Sickle cell disease, involving abnormal hemoglobin

ASJC Scopus subject areas

  • Medicine(all)


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