Should plasma be transfused prophylactically before invasive procedures?

Lorne Holland, Ravindra Sarode

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


PURPOSE OF REVIEW: Plasma transfusion to correct abnormal coagulation test results prior to an invasive procedure is a common clinical practice; however, there are no evidence-based guidelines. This review aims to analyze the most recent publications to either support or disprove such practice. RECENT FINDINGS: Due to heightened awareness of transfusion-related acute lung injury and volume overload in susceptible patients, clinicians are increasingly questioning the validity of prophylactic plasma transfusion. Recently, several articles, reviews and clinical studies (although small and poorly designed) have shown no benefit of prophylactic plasma transfusion in either correcting abnormal coagulation tests or reducing perceived risk of hemorrhage. SUMMARY: The use of sensitive reagents (especially for prothrombin time) has resulted in increased incidence of abnormal preprocedure coagulation screening test results - tests that are not designed to assess risk of bleeding in patients without a history of bleeding. Transfusion of plasma prior to an invasive procedure to correct mild to moderate abnormal test results neither corrects the abnormality nor reduces the perceived bleeding risk.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalCurrent opinion in hematology
Issue number6
StatePublished - Nov 2006


  • Bleeding
  • Fresh frozen plasma
  • International normalized ratio
  • Prothrombin time
  • Transfusion-related acute lung injury

ASJC Scopus subject areas

  • Hematology


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