Short-chain organic acidemia and reye’s syndrome

Doris A. Trauner, William L. Nyhan, Lawrence Sweetman

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Short-chain fatty acids were determined prior to therapy in seven patients with Reye’s syndrome. Elevated concentrations of propionate, butyrate, and isobutyrate were found in all patients. lsovalerate concentrations were high in three patients. In view of the fact that the administration of certain short-chain fatty acids to experimental animals results in coma, electroencephalographic changes, and fatty accumulation in the viscera, the elevations of short-chain fatty acid concentrations observed in the present study suggest that these fatty acids may play a role in the clinical manifestations of Reye’s syndrome.

Original languageEnglish (US)
Pages (from-to)296-298
Number of pages3
Issue number3
StatePublished - Mar 1975
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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