TY - JOUR
T1 - Shape-specific polymeric nanomedicine
T2 - Emerging opportunities and challenges
AU - Tao, Li
AU - Hu, Walter
AU - Liu, Yaling
AU - Huang, Gang
AU - Sumer, Baran D.
AU - Gao, Jinming
N1 - Funding Information:
This work is supported by the Department of the Army (W81XWH-BAA08) and Montcrief Foundation (WH and JG), the National Science Foundation (CBET-0955214) and National Institutes of Health (EB009786) (YL), and American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) through the Percy Memorial Research Award to BDS. GH is supported by a Susan G Komen foundation postdoctoral fellowship (PDF0707216).
PY - 2011/1
Y1 - 2011/1
N2 - Size and shape are fundamental properties of micro/nanoparticles that are critically important for nanomedicine applications. Extensive studies have revealed the effect of particle size on spherical particles with respect to circulation, extravasation and distribution in vivo. In contrast, the importance of particle shape has only recently begun to emerge. For example, cylindrically-shaped filomicelles (diameter 22-60 nm, length 8-18 μm) have shown persistent blood circulation for up to one week after intravenous injection, much longer than their spherical counterparts. Disc-shaped nanoparticles have demonstrated higher in vivo targeting specificity to endothelial cells expressing intercellular adhesion molecule receptors in mice than spherical particles of similar size. In this Minireview, we will discuss the recent advances in the fabrication of shape-specific nanoparticles and their unique biological and pharmacological properties. Computational models are presented to provide mechanistic understanding of the shape effects on cell targeting under flow conditions. Shape-specific nanoparticles have the potential to significantly improve the performance of nanomedicine in diagnostic imaging and targeted drug delivery applications.
AB - Size and shape are fundamental properties of micro/nanoparticles that are critically important for nanomedicine applications. Extensive studies have revealed the effect of particle size on spherical particles with respect to circulation, extravasation and distribution in vivo. In contrast, the importance of particle shape has only recently begun to emerge. For example, cylindrically-shaped filomicelles (diameter 22-60 nm, length 8-18 μm) have shown persistent blood circulation for up to one week after intravenous injection, much longer than their spherical counterparts. Disc-shaped nanoparticles have demonstrated higher in vivo targeting specificity to endothelial cells expressing intercellular adhesion molecule receptors in mice than spherical particles of similar size. In this Minireview, we will discuss the recent advances in the fabrication of shape-specific nanoparticles and their unique biological and pharmacological properties. Computational models are presented to provide mechanistic understanding of the shape effects on cell targeting under flow conditions. Shape-specific nanoparticles have the potential to significantly improve the performance of nanomedicine in diagnostic imaging and targeted drug delivery applications.
KW - Cell targeting
KW - Drug delivery
KW - Intravascular dynamics
KW - Non-spherical nanoparticles
KW - Shape-specific nanomedicine
KW - Top-down engineering method
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U2 - 10.1258/ebm.2010.010243
DO - 10.1258/ebm.2010.010243
M3 - Review article
C2 - 21239732
AN - SCOPUS:78751508035
SN - 1535-3702
VL - 236
SP - 20
EP - 29
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 1
ER -