TY - JOUR
T1 - SGLT2 inhibition and heart failure—current concepts
AU - Custodio, Joaquim Silva
AU - Duraes, Andre Rodrigues
AU - Abreu, Marconi
AU - Albuquerque Rocha, Natalia
AU - Roever, Leonardo
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Type 2 diabetes mellitus (T2DM) is a major risk factor for several cardiovascular (CV) conditions, including heart failure (HF). However, until recently, no therapy to treat patients with diabetes could also reduce CV risks related to HF. The EMPA-REG OUTCOME trial with empagliflozin was the first to demonstrate significant cardioprotective benefits in this population. Its impressive 35% reduction in hospitalizations for HF drew the attention of the scientific community to the possibility that pharmacologic sodium-glucose cotransporter 2 (SGLT2) inhibition could be part of the armamentarium for treating patients with HF, with and without diabetes. The recently published CANVAS Program (with canagliflozin) and real-life data from the CVD-Real Study (using dapagliflozin, empagliflozin, and canagliflozin) further strengthened this hypothesis, suggesting that the observed benefit is not restricted to a particular drug, but is rather a class effect. This review explores the effects of pharmacologic SGLT2 inhibitors’ use in cardiac function and discusses the potential role of this class of medication as a treatment for HF.
AB - Type 2 diabetes mellitus (T2DM) is a major risk factor for several cardiovascular (CV) conditions, including heart failure (HF). However, until recently, no therapy to treat patients with diabetes could also reduce CV risks related to HF. The EMPA-REG OUTCOME trial with empagliflozin was the first to demonstrate significant cardioprotective benefits in this population. Its impressive 35% reduction in hospitalizations for HF drew the attention of the scientific community to the possibility that pharmacologic sodium-glucose cotransporter 2 (SGLT2) inhibition could be part of the armamentarium for treating patients with HF, with and without diabetes. The recently published CANVAS Program (with canagliflozin) and real-life data from the CVD-Real Study (using dapagliflozin, empagliflozin, and canagliflozin) further strengthened this hypothesis, suggesting that the observed benefit is not restricted to a particular drug, but is rather a class effect. This review explores the effects of pharmacologic SGLT2 inhibitors’ use in cardiac function and discusses the potential role of this class of medication as a treatment for HF.
KW - Cardiovascular outcomes
KW - Diabetes mellitus
KW - Heart failure
KW - SGLT2 inhibitors
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U2 - 10.1007/s10741-018-9703-2
DO - 10.1007/s10741-018-9703-2
M3 - Review article
C2 - 29704192
AN - SCOPUS:85046015697
SN - 1382-4147
VL - 23
SP - 409
EP - 418
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 3
ER -