Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022

CDC Severe Monkeypox Investigations Team

doi:10.15585/MMWR.MM7144E1

Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022

CDC Severe Monkeypox Investigations Team

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

What is already known about this topic? Severe manifestations of monkeypox in immunocompromised persons have been observed in previous outbreaks. What is added by this report? During August-October 2022, CDC provided clinical consultation for 57 hospitalized patients with severe manifestations of monkeypox, most of whom were Black men with AIDS. Delays were observed in initiation of monkeypox-directed therapies. Twelve patients died, and monkeypox was a cause of death or contributing factor in five patients to date, with several other deaths still under investigation. What are the implications for public health practice? Clinicians should consider early treatment with available therapeutics for those at risk for severe monkeypox disease, particularly patients with AIDS. Engaging all persons with HIV in care remains a critical public health priority.

Original language	English (US)
Pages (from-to)	1412-1417
Number of pages	6
Journal	Morbidity and Mortality Weekly Report
Volume	71
Issue number	44
DOIs	https://doi.org/10.15585/MMWR.MM7144E1
State	Published - Nov 4 2022

ASJC Scopus subject areas

Epidemiology
Health(social science)
Health, Toxicology and Mutagenesis
Health Information Management

Access to Document

10.15585/MMWR.MM7144E1

Cite this

@article{feb5b4d62842470ba69af63bd4156ec9,

title = "Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022",

abstract = "What is already known about this topic? Severe manifestations of monkeypox in immunocompromised persons have been observed in previous outbreaks. What is added by this report? During August-October 2022, CDC provided clinical consultation for 57 hospitalized patients with severe manifestations of monkeypox, most of whom were Black men with AIDS. Delays were observed in initiation of monkeypox-directed therapies. Twelve patients died, and monkeypox was a cause of death or contributing factor in five patients to date, with several other deaths still under investigation. What are the implications for public health practice? Clinicians should consider early treatment with available therapeutics for those at risk for severe monkeypox disease, particularly patients with AIDS. Engaging all persons with HIV in care remains a critical public health priority.",

author = "{CDC Severe Monkeypox Investigations Team} and Miller, {Maureen J.} and Shama Cash-Goldwasser and Marx, {Grace E.} and Schrodt, {Caroline A.} and Anne Kimball and Kia Padgett and Noe, {Rebecca S.} and McCormick, {David W.} and Wong, {Joshua M.} and Labuda, {Sarah M.} and Borah, {Brian F.} and Isaac Zulu and Amimah Asif and Gurpreet Kaur and McNicholl, {Janet M.} and Athena Kourtis and Andrew Tadros and Sarah Reagan-Steiner and Ritter, {Jana M.} and Yon Yu and Patricia Yu and Rachel Clinton and Corrine Parker and Click, {Eleanor S.} and Salzer, {Johanna S.} and McCollum, {Andrea M.} and Brett Petersen and Minhaj, {Faisal S.} and Ericka Brown and Fischer, {Michael P.} and Atmar, {Robert L.} and {Di Nardo}, {Andrew R.} and Ya Xu and Cameron Brown and Goodman, {Jerry Clay} and Ashley Holloman and Julia Gallardo and Hanna Siatecka and Georgia Huffman and John Powell and Philip Alapat and Pralay Sarkar and Hanania, {Nicola A.} and Or Bruck and Brass, {Steven D.} and Susana Lazarte and Perl, {Trish M.} and Jeremy Chow and Ellen Kitchell and Ank Nijhawan",

year = "2022",

month = nov,

day = "4",

doi = "10.15585/MMWR.MM7144E1",

language = "English (US)",

volume = "71",

pages = "1412--1417",

journal = "Morbidity and Mortality Weekly Report",

issn = "0149-2195",

publisher = "Department of Health and Human Services",

number = "44",

}

TY - JOUR

T1 - Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022

AU - CDC Severe Monkeypox Investigations Team

AU - Miller, Maureen J.

AU - Cash-Goldwasser, Shama

AU - Marx, Grace E.

AU - Schrodt, Caroline A.

AU - Kimball, Anne

AU - Padgett, Kia

AU - Noe, Rebecca S.

AU - McCormick, David W.

AU - Wong, Joshua M.

AU - Labuda, Sarah M.

AU - Borah, Brian F.

AU - Zulu, Isaac

AU - Asif, Amimah

AU - Kaur, Gurpreet

AU - McNicholl, Janet M.

AU - Kourtis, Athena

AU - Tadros, Andrew

AU - Reagan-Steiner, Sarah

AU - Ritter, Jana M.

AU - Yu, Yon

AU - Yu, Patricia

AU - Clinton, Rachel

AU - Parker, Corrine

AU - Click, Eleanor S.

AU - Salzer, Johanna S.

AU - McCollum, Andrea M.

AU - Petersen, Brett

AU - Minhaj, Faisal S.

AU - Brown, Ericka

AU - Fischer, Michael P.

AU - Atmar, Robert L.

AU - Di Nardo, Andrew R.

AU - Xu, Ya

AU - Brown, Cameron

AU - Goodman, Jerry Clay

AU - Holloman, Ashley

AU - Gallardo, Julia

AU - Siatecka, Hanna

AU - Huffman, Georgia

AU - Powell, John

AU - Alapat, Philip

AU - Sarkar, Pralay

AU - Hanania, Nicola A.

AU - Bruck, Or

AU - Brass, Steven D.

AU - Lazarte, Susana

AU - Perl, Trish M.

AU - Chow, Jeremy

AU - Kitchell, Ellen

AU - Nijhawan, Ank

PY - 2022/11/4

Y1 - 2022/11/4

N2 - What is already known about this topic? Severe manifestations of monkeypox in immunocompromised persons have been observed in previous outbreaks. What is added by this report? During August-October 2022, CDC provided clinical consultation for 57 hospitalized patients with severe manifestations of monkeypox, most of whom were Black men with AIDS. Delays were observed in initiation of monkeypox-directed therapies. Twelve patients died, and monkeypox was a cause of death or contributing factor in five patients to date, with several other deaths still under investigation. What are the implications for public health practice? Clinicians should consider early treatment with available therapeutics for those at risk for severe monkeypox disease, particularly patients with AIDS. Engaging all persons with HIV in care remains a critical public health priority.

AB - What is already known about this topic? Severe manifestations of monkeypox in immunocompromised persons have been observed in previous outbreaks. What is added by this report? During August-October 2022, CDC provided clinical consultation for 57 hospitalized patients with severe manifestations of monkeypox, most of whom were Black men with AIDS. Delays were observed in initiation of monkeypox-directed therapies. Twelve patients died, and monkeypox was a cause of death or contributing factor in five patients to date, with several other deaths still under investigation. What are the implications for public health practice? Clinicians should consider early treatment with available therapeutics for those at risk for severe monkeypox disease, particularly patients with AIDS. Engaging all persons with HIV in care remains a critical public health priority.

UR - http://www.scopus.com/inward/record.url?scp=85141890650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85141890650&partnerID=8YFLogxK

U2 - 10.15585/MMWR.MM7144E1

DO - 10.15585/MMWR.MM7144E1

M3 - Article

C2 - 36327164

AN - SCOPUS:85141890650

SN - 0149-2195

VL - 71

SP - 1412

EP - 1417

JO - Morbidity and Mortality Weekly Report

JF - Morbidity and Mortality Weekly Report

IS - 44

ER -

Severe Monkeypox in Hospitalized Patients - United States, August 10-October 10, 2022

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this