Serum neuron‐specific enolase in metastatic merkel cell tumors

L. Giannone, D. H. Johnson, W. W. Grosh, B. W. Davis, P. J. Marangos, F. A. Greco

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Three patients with widely disseminated Merkel cell tumors of the skin are presented. In all three cases, neuron‐specific enolase (NSE) was demonstrated in neoplastic tissue by immunohistochemical staining, and serum NSE levels were also elevated in all three patients. Serum NSE may prove to be a useful tumor marker in this and other malignancies of neuroendocrine origin.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalMedical and Pediatric Oncology
Issue number6
StatePublished - 1985


  • Merkel cell tumor
  • neuron‐specific enolase

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research


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