TY - JOUR
T1 - Sertraline in the treatment of depression in the elderly
AU - McClintock, Shawn M.
AU - Queenan, Kip
AU - Faniran, Olayemi
AU - Ranginwala, Najeeb
AU - Husain, Mustafa M.
PY - 2006/4
Y1 - 2006/4
N2 - Sertraline is a selective serotonin reuptake inhibitor used to treat major depressive disorder. It is approved by the US FDA for the treatment of depression, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder, postmenopausal dysphoric disorder and panic disorder. Sertraline selectively inhibits the CNS neuronal reuptake of serotonin, with a steady-state plasma concentration reached after approximately 1 week and taking 2-3 weeks longer in older adults. The average elimination half-life of plasma sertraline is approximately 26 h, and it is principally excreted renally as ketone and alcohol conjugates. Sertraline is generally safe, well tolerated and convenient to prescribe for elderly patients. Ongoing research is studying the use of sertraline in the treatment of geriatric depression and other psychiatric condition.
AB - Sertraline is a selective serotonin reuptake inhibitor used to treat major depressive disorder. It is approved by the US FDA for the treatment of depression, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder, postmenopausal dysphoric disorder and panic disorder. Sertraline selectively inhibits the CNS neuronal reuptake of serotonin, with a steady-state plasma concentration reached after approximately 1 week and taking 2-3 weeks longer in older adults. The average elimination half-life of plasma sertraline is approximately 26 h, and it is principally excreted renally as ketone and alcohol conjugates. Sertraline is generally safe, well tolerated and convenient to prescribe for elderly patients. Ongoing research is studying the use of sertraline in the treatment of geriatric depression and other psychiatric condition.
KW - Geriatric depression
KW - Major depressive disorder
KW - Selective serotonin reuptake inhibitors
KW - Sertraline
UR - http://www.scopus.com/inward/record.url?scp=33646568097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646568097&partnerID=8YFLogxK
U2 - 10.2217/1745509X.2.2.199
DO - 10.2217/1745509X.2.2.199
M3 - Article
AN - SCOPUS:33646568097
SN - 1745-509X
VL - 2
SP - 199
EP - 208
JO - Aging Health
JF - Aging Health
IS - 2
ER -