Serotonin in the raphe nuclei: Regulation by light and an endogenous pacemaker

F. R A Cagampang; S. Yamazaki; Y. Otori; S. T. Inouye

doi:10.1097/00001756-199310000-00012

Serotonin in the raphe nuclei: Regulation by light and an endogenous pacemaker

F. R A Cagampang, S. Yamazaki, Y. Otori, S. T. Inouye

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.

Original language	English (US)
Pages (from-to)	49-52
Number of pages	4
Journal	NeuroReport
Volume	5
Issue number	1
DOIs	https://doi.org/10.1097/00001756-199310000-00012
State	Published - Oct 1993

Keywords

Circadian rhythm
HPLC
Raphe nuclei
Rat
Serotonin

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199310000-00012

Cite this

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abstract = "Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.",

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AU - Cagampang, F. R A

AU - Yamazaki, S.

AU - Otori, Y.

AU - Inouye, S. T.

PY - 1993/10

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N2 - Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.

AB - Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark phase. In constant dark (DD) condition, a single peak was observed and was out of phase to the 5-HT peak found under LD condition. Animals exposed to constant light (LL) after 2 days in DD showed marked increase in 5-HT after lights on. These results suggest that changes in 5-HT in the MRN and DRN are regulated by an endogenous pacemaker and by light.

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Serotonin in the raphe nuclei: Regulation by light and an endogenous pacemaker

Abstract

Keywords

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