Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt, Yuwei Zhu, Carlos G. Grijalva, Richard G. Wunderink, D. Mark Courtney, Grant Waterer, Min Z. Levine, Stacie Jefferson, Wesley H. Self, Derek J. Williams, Lynn Finelli, Anna M. Bramley, Kathryn M. Edwards, Seema Jain, Evan J. Anderson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalInfluenza and other respiratory viruses
Issue number2
StatePublished - Mar 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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