Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt; Yuwei Zhu; Carlos G. Grijalva; Richard G. Wunderink; D. Mark Courtney; Grant Waterer; Min Z. Levine; Stacie Jefferson; Wesley H. Self; Derek J. Williams; Lynn Finelli; Anna M. Bramley; Kathryn M. Edwards; Seema Jain; Evan J. Anderson

doi:10.1111/irv.12622

Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

Caroline Quinn Pratt, Yuwei Zhu, Carlos G. Grijalva, Richard G. Wunderink, D. Mark Courtney, Grant Waterer, Min Z. Levine, Stacie Jefferson, Wesley H. Self, Derek J. Williams, Lynn Finelli, Anna M. Bramley, Kathryn M. Edwards, Seema Jain, Evan J. Anderson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.

Original language	English (US)
Pages (from-to)	208-212
Number of pages	5
Journal	Influenza and other respiratory viruses
Volume	13
Issue number	2
DOIs	https://doi.org/10.1111/irv.12622
State	Published - Mar 1 2019
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1111/irv.12622

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Pratt, C. Q., Zhu, Y., Grijalva, C. G., Wunderink, R. G., Mark Courtney, D., Waterer, G., Levine, M. Z., Jefferson, S., Self, W. H., Williams, D. J., Finelli, L., Bramley, A. M., Edwards, K. M., Jain, S., & Anderson, E. J. (2019). Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia. Influenza and other respiratory viruses, 13(2), 208-212. https://doi.org/10.1111/irv.12622

Pratt, CQ, Zhu, Y, Grijalva, CG, Wunderink, RG, Mark Courtney, D, Waterer, G, Levine, MZ, Jefferson, S, Self, WH, Williams, DJ, Finelli, L, Bramley, AM, Edwards, KM, Jain, S & Anderson, EJ 2019, 'Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia', Influenza and other respiratory viruses, vol. 13, no. 2, pp. 208-212. https://doi.org/10.1111/irv.12622

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title = "Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia",

abstract = "Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.",

author = "Pratt, {Caroline Quinn} and Yuwei Zhu and Grijalva, {Carlos G.} and Wunderink, {Richard G.} and {Mark Courtney}, D. and Grant Waterer and Levine, {Min Z.} and Stacie Jefferson and Self, {Wesley H.} and Williams, {Derek J.} and Lynn Finelli and Bramley, {Anna M.} and Edwards, {Kathryn M.} and Seema Jain and Anderson, {Evan J.}",

note = "Funding Information: Supported by the Influenza Division, National Center for Immunization and Respiratory Diseases, CDC through cooperative agreements with each study site. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. Funding Information: WHS reports research funding from Merck & Co Inc, Pfizer, Gilead Sciences, and Ferring Pharmaceuticals, and consultant fees from Cempra Pharmaceuticals, Ferring Pharmaceuticals, and BioTest AG. EJA reports prior consulting for AbbVie, research funding from MedImmune, Regeneron, Pfizer, Merck &Co Inc, PaxVax, and Sanofi Pasteur. Publisher Copyright: {\textcopyright} 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.",

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AU - Waterer, Grant

AU - Levine, Min Z.

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AU - Self, Wesley H.

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AU - Bramley, Anna M.

AU - Edwards, Kathryn M.

AU - Jain, Seema

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Serological response to influenza vaccination among adults hospitalized with community-acquired pneumonia

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