TY - CHAP
T1 - Sensitivity enhancement of NIR fluorescence contrast agent utilizing gold nanoparticles
AU - Kang, Kyung A.
AU - Wang, Jianting
AU - O'Toole, Martin G.
AU - Nantz, Michael
AU - Moore, Joseph D.
AU - Laulhe, Sebastien
AU - Achilefu, Samuel
N1 - Funding Information:
The authors acknowledge the financial support from the U.S. Army Breast Cancer Program.
PY - 2012
Y1 - 2012
N2 - For optical diagnosis of the human body, using near infrared (NIR) has several advantages: NIR penetrates into the tissue deeper than UV or visible light, and in NIR most of the tissue-originated fluorescence may be avoided. Although NIR fluorophores are valuable, only a few can be used for humans and they have relatively low quantum yields. If the fluorescence emission of NIR fluorophores can be artificially enhanced, it can increase the sensitivity of optical diagnosis. In addition, conditionally emitted contrast agents as in Förster resonance energy transfer (FRET) or molecular beacon can be developed. One way of artificially changing fluorescence is by applying an electric field to the fluorophore. An excellent way of generating the field is via the plasmon field by gold nanoparticles (GNPs) upon the receipt of the excitation light of the fluorophore to be used. In this paper, the mechanism of the fluorescence manipulation for an NIR fluorophore, Cypate, by GNPs is studied both theoretically and experimentally.
AB - For optical diagnosis of the human body, using near infrared (NIR) has several advantages: NIR penetrates into the tissue deeper than UV or visible light, and in NIR most of the tissue-originated fluorescence may be avoided. Although NIR fluorophores are valuable, only a few can be used for humans and they have relatively low quantum yields. If the fluorescence emission of NIR fluorophores can be artificially enhanced, it can increase the sensitivity of optical diagnosis. In addition, conditionally emitted contrast agents as in Förster resonance energy transfer (FRET) or molecular beacon can be developed. One way of artificially changing fluorescence is by applying an electric field to the fluorophore. An excellent way of generating the field is via the plasmon field by gold nanoparticles (GNPs) upon the receipt of the excitation light of the fluorophore to be used. In this paper, the mechanism of the fluorescence manipulation for an NIR fluorophore, Cypate, by GNPs is studied both theoretically and experimentally.
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U2 - 10.1007/978-1-4614-1566-4_42
DO - 10.1007/978-1-4614-1566-4_42
M3 - Chapter
C2 - 22259115
AN - SCOPUS:84863047122
SN - 9781461415657
T3 - Advances in Experimental Medicine and Biology
SP - 285
EP - 291
BT - Oxygen Transport to Tissue XXXIII
ER -