Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Christos Stathopoulos; David R. Hendrixson; David G. Thanassi; Scott J. Hultgren; Joseph W. St. Geme; Roy Curtiss

doi:10.1016/S1286-4579(00)01260-0

Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Christos Stathopoulos, David R. Hendrixson, David G. Thanassi, Scott J. Hultgren, Joseph W. St. Geme, Roy Curtiss

Research output: Contribution to journal › Review article › peer-review

130 Scopus citations

Abstract

Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original language	English (US)
Pages (from-to)	1061-1072
Number of pages	12
Journal	Microbes and Infection
Volume	2
Issue number	9
DOIs	https://doi.org/10.1016/S1286-4579(00)01260-0
State	Published - 2000

Keywords

Autotransporters
Curli
Elsevier SAS Gram-negative bacteria
General secretory pathway
Pili
Pullulanase
S-layers
Sec translocase
Toxins

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/S1286-4579(00)01260-0

Cite this

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title = "Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story",

abstract = "Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.",

keywords = "Autotransporters, Curli, Elsevier SAS Gram-negative bacteria, General secretory pathway, Pili, Pullulanase, S-layers, Sec translocase, Toxins",

author = "Christos Stathopoulos and Hendrixson, {David R.} and Thanassi, {David G.} and Hultgren, {Scott J.} and {St. Geme}, {Joseph W.} and Roy Curtiss",

note = "Funding Information: We would like to thank Charles M. Dozois, France Daigle, Kone Kaniga, Barbara N. Kunkel, and the anonymous reviewer for providing many helpful comments on the manuscript. Work in the RC laboratory is supported by grants provided from NIH (R01 AI24533) and USDA (94–37204–1091). Work in the SJH laboratory is supported by NIH R01 AI29549 and NIH R01 DK51406 grants. Work in the JWS laboratory is supported by NIH R01 AI/DC44167, NIH R01 DC02873, an American Heart Association Established Investigator Award, and a March of Dimes research grant. CS was recipient of an NIH Research Service Award Traineeship (AI07172–20).",

year = "2000",

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T2 - An evolving story

AU - Stathopoulos, Christos

AU - Hendrixson, David R.

AU - Thanassi, David G.

AU - Hultgren, Scott J.

AU - St. Geme, Joseph W.

AU - Curtiss, Roy

N1 - Funding Information: We would like to thank Charles M. Dozois, France Daigle, Kone Kaniga, Barbara N. Kunkel, and the anonymous reviewer for providing many helpful comments on the manuscript. Work in the RC laboratory is supported by grants provided from NIH (R01 AI24533) and USDA (94–37204–1091). Work in the SJH laboratory is supported by NIH R01 AI29549 and NIH R01 DK51406 grants. Work in the JWS laboratory is supported by NIH R01 AI/DC44167, NIH R01 DC02873, an American Heart Association Established Investigator Award, and a March of Dimes research grant. CS was recipient of an NIH Research Service Award Traineeship (AI07172–20).

PY - 2000

Y1 - 2000

N2 - Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

AB - Secretion of proteins by the general secretory pathway (GSP) is a two- step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

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Secretion of virulence determinants by the general secretory pathway in Gram-negative pathogens: An evolving story

Abstract

Keywords

ASJC Scopus subject areas

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