Schizophrenic symptoms improve with apomorphine

Carol A. Tamminga; Martin H. Schaffer; Robert C. Smith; John M. Davis

doi:10.1126/science.347574

Schizophrenic symptoms improve with apomorphine

Carol A. Tamminga, Martin H. Schaffer, Robert C. Smith, John M. Davis

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196 Scopus citations

Abstract

Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

Original language	English (US)
Pages (from-to)	567-568
Number of pages	2
Journal	Science
Volume	200
Issue number	4341
DOIs	https://doi.org/10.1126/science.347574
State	Published - 1978

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title = "Schizophrenic symptoms improve with apomorphine",

abstract = "Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.",

author = "Tamminga, {Carol A.} and Schaffer, {Martin H.} and Smith, {Robert C.} and Davis, {John M.}",

year = "1978",

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AB - Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

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Schizophrenic symptoms improve with apomorphine

Abstract

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