@article{b8adec92945140b28c25952458296545,
title = "Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection",
abstract = "Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.",
keywords = "CD209, Dendritic cell, Dissemination, Lipooligosaccharide, Macrophages, S. Typhimurium",
author = "Chenglin Ye and Qiao Li and Xinyi Li and Park, {Chae Gyu} and Yingxia He and Yingmiao Zhang and Bicong Wu and Ying Xue and Kun Yang and Yin Lv and Ying, {Xiao Ling} and Ding, {Hong Hui} and Huahua Cai and Alkraiem, {Ayman Ahmad} and Olivia Njiri and John Tembo and Huang, {Hong Ping} and Li, {An Yi} and Jianping Gong and Jichao Qin and Bing Cheng and Xiang Wei and Ziyong Sun and Zhang, {Shu Sheng} and Pei Zhang and Zheng, {Guo Xing} and Wei Li and Biao Kan and Meiying Yan and Xiamu Xiding and Xixiang Huo and Yingchun Zeng and Hua Peng and Yangxin Fu and Klena, {John D.} and Mikael Skurnik and Jiang, {Ling Yu} and Tie Chen",
note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (NSFC 81271780 and 81471915 [T.C.] and 81602722 [L.-Y.J.]) and by two local grants from Tongji Hospital, Tongji Medical College (T.C.). C.G.P. was supported by grants from the National Research Foundation of Korea (NRF-2013R1A1A2058427 and NRF-2014R1A4A1008625) and a faculty research grant from Yonsei University College of Medicine for 2014 (6-2014-0062). Publisher Copyright: {\textcopyright} 2019 American Society for Microbiology. All Rights Reserved.",
year = "2019",
doi = "10.1128/IAI.00100-19",
language = "English (US)",
volume = "87",
journal = "Infection and immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "8",
}