Salmonella enterica serovar typhimurium interacts with CD209 receptors to promote host dissemination and infection

Chenglin Ye, Qiao Li, Xinyi Li, Chae Gyu Park, Yingxia He, Yingmiao Zhang, Bicong Wu, Ying Xue, Kun Yang, Yin Lv, Xiao Ling Ying, Hong Hui Ding, Huahua Cai, Ayman Ahmad Alkraiem, Olivia Njiri, John Tembo, Hong Ping Huang, An Yi Li, Jianping Gong, Jichao QinBing Cheng, Xiang Wei, Ziyong Sun, Shu Sheng Zhang, Pei Zhang, Guo Xing Zheng, Wei Li, Biao Kan, Meiying Yan, Xiamu Xiding, Xixiang Huo, Yingchun Zeng, Hua Peng, Yangxin Fu, John D. Klena, Mikael Skurnik, Ling Yu Jiang, Tie Chen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Salmonella enterica serovar Typhimurium, a Gram-negative bacterium, can cause infectious diseases ranging from gastroenteritis to systemic dissemination and infection. However, the molecular mechanisms underlying this bacterial dissemination have yet to be elucidated. A study indicated that using the lipopolysaccharide (LPS) core as a ligand, S. Typhimurium was able to bind human dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (hCD209a), an HIV receptor that promotes viral dissemination by hijacking antigen-presenting cells (APCs). In this study, we showed that S. Typhimurium interacted with CD209s, leading to the invasion of APCs and potentially the dissemination to regional lymph nodes, spleen, and liver in mice. Shielding of the exposed LPS core through the expression of O-antigen reduces dissemination and infection. Thus, we propose that similar to HIV, S. Typhimurium may also utilize APCs via interactions with CD209s as a way to disseminate to the lymph nodes, spleen, and liver to initiate host infection.

Original languageEnglish (US)
Article numbere00100
JournalInfection and immunity
Issue number8
StatePublished - 2019


  • CD209
  • Dendritic cell
  • Dissemination
  • Lipooligosaccharide
  • Macrophages
  • S. Typhimurium

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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