Safety recommendations for administering intravenous prostacyclins in the Hospital

Martha S. Kingman, Kelly Chin

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Prostacyclins are a high-risk category of continuous intravenous infusions increasingly used in hospitals to treat advanced pulmonary arterial hypertension, a rare condition characterized by vasoconstriction and vascular proliferation of the pulmonary arteries. Prostacyclins are given in doses of nanograms per kilogram per minute and have a narrow therapeutic dosing range for each patient. Sudden increases or decreases in dose can be life threatening. Previous studies revealed errors in the administration of these high-risk infusions, which in some instances led to serious adverse events, including death. The literature was reviewed for safety measures in administration of high-risk intravenous medications and input was obtained from leading experts in pulmonary arterial hypertension to create a set of safety recommendations for infusion of prostacyclins.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalCritical care nurse
Issue number5
StatePublished - 2013

ASJC Scopus subject areas

  • Critical Care


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