TY - JOUR
T1 - Roles of Caspases in Necrotic Cell Death
AU - Yuan, Junying
AU - Najafov, Ayaz
AU - Py, Bénédicte F.
N1 - Funding Information:
This work was supported in part by grants to J.Y. from the NINDS-US (1R01NS082257) and the NIA-US (1R01AG047231) and to B.P. from the European Research Council (ERC-2013-CoG_616986). We thank Palak Amin and Albert D. Yu for comments on the manuscript.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/15
Y1 - 2016/12/15
N2 - Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.
AB - Caspases were originally identified as important mediators of inflammatory response and apoptosis. Recent discoveries, however, have unveiled their roles in mediating and suppressing two regulated forms of necrotic cell death, termed pyroptosis and necroptosis, respectively. These recent advances have significantly expanded our understanding of the roles of caspases in regulating development, adult homeostasis, and host defense response.
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U2 - 10.1016/j.cell.2016.11.047
DO - 10.1016/j.cell.2016.11.047
M3 - Review article
C2 - 27984721
AN - SCOPUS:85006248546
SN - 0092-8674
VL - 167
SP - 1693
EP - 1704
JO - Cell
JF - Cell
IS - 7
ER -