TY - CHAP
T1 - Role of r-ras in cell growth
AU - Repasky, Gretchen A.
AU - Cox, Adrienne D.
AU - Hanker, Ariella B.
AU - Mitin, Natalia
AU - Der, Channing J.
N1 - Funding Information:
We thank Lanika DeGraffenreid for expert assistance with manuscript and figure preparation. Our studies were supported by grant CA042978 from the National Cancer Institute (to Channing J. Der). Ariella B. Hanker was supported by a Department of Defense Breast Cancer Research Program predoctoral fellowship (W81XWH-06-1-0747).
PY - 2010
Y1 - 2010
N2 - This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.
AB - This chapter summarizes the general features of R-Ras proteins that are shared with Ras proteins, and then highlights unique features of each R-Ras protein. Ras proteins (H-Ras, K-Ras4A and 4B, and N-Ras) are regulators of signal transduction, mutated in 30 percent of human cancers, and targets for novel approaches for cancer treatment. Ras proteins are the founding members of a superfamily of small GTP binding and hydrolyzing proteins. The three R-Ras subfamily members, R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3, mediate cell growth, division, differentiation, and death by utilizing both novel pathways and those regulated by Ras and other Ras-related proteins. Further, R-Ras subfamily members, especially R-Ras itself, contribute to cellular processes such as integrin-mediated cell adhesion in a manner distinct from that of Ras. Deciphering the full contribution of R-Ras, TC21, and M-Ras to cellular growth control clearly awaits further study.
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U2 - 10.1016/B978-0-12-374145-5.00214-X
DO - 10.1016/B978-0-12-374145-5.00214-X
M3 - Chapter
AN - SCOPUS:84882835540
SN - 9780123741455
VL - 2
SP - 1753
EP - 1762
BT - Handbook of Cell Signaling, 2/e
PB - Elsevier Inc.
ER -