Role of Insulin in the Hepatic Handling of Glucose

L. L. Madison

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The effects of insulin on hepatic glucose balance, including data on hepatic glucose output, production (glycogenolysis and gluconeogenesis), and uptake in normal and diabetic animals are reviewed. Data from in vivo studies are presented which indicate that these changes in the hepatic handling of glucose following insulin administration are direct effects of insulin on the liver rather than effects secondary to insulin’s action on muscle and adipose tissue. These studies indicate that these hepatic actions of insulin are vital to the organism both during feasting and prolonged fasting.

Original languageEnglish (US)
Pages (from-to)284-292
Number of pages9
JournalArchives of Internal Medicine
Issue number3
StatePublished - Mar 1969

ASJC Scopus subject areas

  • Internal Medicine


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