Role of cardiac output in the pressor responses to graded muscle ischemia in man

F. Bonde-Petersen, L. B. Rowell, R. G. Murray, G. G. Blomqvist, R. White, E. Karlsson, W. Campbell, J. H. Mitchell

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Ten men repeatedly performed leg exercise (100-150 W) for 7 min with 30-min recovery periods interspersed. Both legs were made ischemic by total occlusion (OCCL), first for 3 min immediately after exercise and second for 30 s before exercise ended and 3 min into recovery. In addition, legs were occluded for 3 min at rest (seated). OCCL at rest increased mean arterial pressure (MA) by 9 Torr but did not affect cardiac output (CO) or heart rate (HR). OCCL at the end of exercise significantly raised MAP and HR above control values during 3-min recovery but CO was unaffected. OCCL 30 s before the end of exercise further increased MAP and HR significantly during recovery; MAP, CO, and HR were significantly increased above control values (CO by 2.1 l/min) during the 3rd min of recovery. The authors conclude that a strong reflex from ischemic legs maintains normal or elevated CO during leg OCCL. Thus CO was too high relative to total vascular conductance so that MAP was elevated.

Original languageEnglish (US)
Pages (from-to)574-580
Number of pages7
JournalUnknown Journal
Issue number4
StatePublished - 1978

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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