Robust registration method for interventional MRI-guided thermal ablation of prostate cancer

B. Fei, A. Wheaton, Z. Lee, K. Nagano, J. L. Duerk, D. L. Wilson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We are investigating methods to register live-time interventional magnetic resonance imaging (iMRI) slice images with a previously obtained, high resolution MRI image volume. The immediate application is for iMRI-guided treatments of prostate cancer. We created and evaluated a slice-to-volume mutual information registration algorithm for MR images with special features to improve robustness. Features included a multi-resolution approach and automatic restarting to avoid local minima. We acquired 3D volume images from a 1.5 T MRI system and simulated iMRI images. To assess the quality of registration, we calculated 3D displacement on a voxel-by-voxel basis over a volume of interest between slice-to-volume registration and volume-to-volume registrations that were previously shown to be quite accurate. More than 500 registration experiments were performed on MR images of volunteers. The slice-to-volume registration algorithm was very robust for transverse slice images covering the prostate. A 100% success rate was achieved with an acceptance criterion of < 1.0 mm displacement error over the prostate. Our automatic slice-to-volume mutual information registration algorithm is robust and probably sufficiently accurate to aid in the application of iMRI-guided thermal ablation of prostate cancer.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001
Externally publishedYes


  • Image registration
  • Interventional MRI
  • Magnetic resonance imaging (MRI)
  • Minimally invasive treatment
  • Mutual information
  • Prostate cancer
  • Thermal ablation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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