RNA interference pathways in fungi: Mechanisms and functions

Shwu Shin Chang, Zhenyu Zhang, Yi Liu

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations


RNA interference (RNAi) is a conserved eukaryotic gene regulatory mechanism that uses small noncoding RNAs to mediate posttranscriptional/transcriptional gene silencing. The fission yeast Schizosaccharomyces pombe and the filamentous fungus Neurospora crassa have served as important model systems for RNAi research. Studies on these two organisms and other fungi have contributed significantly to our understanding of the mechanisms and functions of RNAi in eukaryotes. In addition, surprisingly diverse RNAi-mediated processes and small RNA biogenesis pathways have been discovered in fungi. In this review, we give an overview of different fungal RNAi pathways with a focus on their mechanisms and functions.

Original languageEnglish (US)
Pages (from-to)305-323
Number of pages19
JournalAnnual Review of Microbiology
StatePublished - Oct 2012


  • Neurospora
  • Schizosaccharomyces pombe
  • small noncoding RNA

ASJC Scopus subject areas

  • Microbiology


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