RNA interference-mediated antiviral defense in insects

Don B. Gammon; Craig C. Mello

doi:10.1016/j.cois.2015.01.006

RNA interference-mediated antiviral defense in insects

Don B. Gammon, Craig C. Mello

Research output: Contribution to journal › Review article › peer-review

120 Scopus citations

Abstract

Abstract Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.

Original language	English (US)
Article number	85
Pages (from-to)	111-120
Number of pages	10
Journal	Current Opinion in Insect Science
Volume	8
DOIs	https://doi.org/10.1016/j.cois.2015.01.006
State	Published - Apr 1 2015

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Insect Science

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10.1016/j.cois.2015.01.006

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title = "RNA interference-mediated antiviral defense in insects",

abstract = "Abstract Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.",

author = "Gammon, {Don B.} and Mello, {Craig C.}",

note = "Funding Information: The authors thank Dr. Darryl Conte and members of the Mello Lab for their constructive comments on the manuscript. Work in the Mello Lab is supported by an NIH grant ( GM058800 ) to C.C.M. C.C.M. is a Howard Hughes Medical Institute Investigator. Funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of this review; and in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",

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doi = "10.1016/j.cois.2015.01.006",

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AU - Gammon, Don B.

AU - Mello, Craig C.

N1 - Funding Information: The authors thank Dr. Darryl Conte and members of the Mello Lab for their constructive comments on the manuscript. Work in the Mello Lab is supported by an NIH grant ( GM058800 ) to C.C.M. C.C.M. is a Howard Hughes Medical Institute Investigator. Funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of this review; and in the decision to submit the manuscript for publication. Publisher Copyright: © 2015 Elsevier Inc. All rights reserved.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Abstract Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.

AB - Abstract Small interfering RNA (siRNA)-mediated RNA interference (RNAi) pathways are critical for the detection and inhibition of RNA virus replication in insects. Recent work has also implicated RNAi pathways in the establishment of persistent virus infections and in the control of DNA virus replication. Accumulating evidence suggests that diverse double-stranded RNAs produced by RNA and DNA viruses can trigger RNAi responses yet many viruses have evolved mechanisms to inhibit RNAi defenses. Therefore, an evolutionary arms race exists between host RNAi pathways and invading viral pathogens. Here we review recent advances in our knowledge of how insect RNAi pathways are elicited upon infection, the strategies used by viruses to counter these defenses, and discuss recent evidence implicating Piwi-interacting RNAs in antiviral defense.

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JO - Current Opinion in Insect Science

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RNA interference-mediated antiviral defense in insects

Abstract

ASJC Scopus subject areas

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