Risk of development of treated retinopathy of prematurity in very low birth weight infants

Samantha Gonski, Susan R. Hupp, C. Michael Cotten, Reese H. Clark, Matthew Laughon, Kevin Watt, Christoph P. Hornik, Karan Kumar, P. Brian Smith, Rachel G. Greenberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: Quantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines. Study design: Among infants ≤1500 g birth weight or ≤30 weeks gestation screened for ROP from 2006–2015, we developed a risk prediction model to identify infants treated for ROP. We applied our model to a separate infant cohort discharged in 2016. Result: Seventy-five thousand eight hundred and twenty one infants met inclusion criteria; 2306 (3%) were treated for ROP. Infants with several risk factor combinations (no ventilator support or oxygen on postnatal day 28, no history of necrotizing enterocolitis, and no intraventricular hemorrhage) were at low risk of ROP. Applied to 6127 infants discharged in 2016, our model had 97.9% sensitivity, 63.3% specificity, positive predictive value of 4.0%, and negative predictive value of 99.9%. Conclusion: Large numbers of infants at low risk of developing ROP are required to undergo screening. Refining current ROP guidelines may reduce unnecessary examinations.

Original languageEnglish (US)
Pages (from-to)1562-1568
Number of pages7
JournalJournal of Perinatology
Issue number11
StatePublished - Nov 1 2019

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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