TY - JOUR
T1 - Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma
AU - Park, Sang Jae
AU - Freise, Chris E.
AU - Hirose, Ryutaro
AU - Kerlan, Robert K.
AU - Yao, Francis Y.
AU - Roberts, John P.
AU - Vagefi, Parsia A.
PY - 2012/7
Y1 - 2012/7
N2 - Loco-regional therapy has been developed to reduce waitlist dropout in patients with hepatocellular carcinoma (HCC) awaiting liver transplantation. We evaluated the probability of transplantation and waitlist dropout, and analyzed risk factors for waitlist dropout, in 76 patients with HCC from September 2004 to August 2006. Seventy-three (96.1%) patients received one or more preoperative loco-regional treatments and 55 (72.3%) received an orthotopic liver transplantation with a median wait time of seven months (range, 2-26 months). There were 11 dropouts (14.5%) associated with tumor progression or hepatic decompensation (median waiting time; 5.4 months and range, 0.4-13 months). Cumulative probabilities of transplantation at three, six, nine, 12, 15, and 18 months were 5.4%, 35.4%, 67.5%, 78.8%, 80.7%, and 80.7%, respectively and those of waitlist dropout at three, six, nine, 12, 15, and 18 months were 3.9%, 8.7%, 12.8%, 22.9%, 29.3%, and 29.3%, respectively. A laboratory model for end-stage liver disease (MELD) score >15 or multiple tumors at the time of UNOS listing were significant risk factors for waitlist dropout (p = 0.006 and 0.026, respectively). Patients with HCC being managed with loco-regional therapy who have a laboratory MELD score >15 or multiple tumors should be considered for earlier access to liver transplantation to prevent waitlist dropout.
AB - Loco-regional therapy has been developed to reduce waitlist dropout in patients with hepatocellular carcinoma (HCC) awaiting liver transplantation. We evaluated the probability of transplantation and waitlist dropout, and analyzed risk factors for waitlist dropout, in 76 patients with HCC from September 2004 to August 2006. Seventy-three (96.1%) patients received one or more preoperative loco-regional treatments and 55 (72.3%) received an orthotopic liver transplantation with a median wait time of seven months (range, 2-26 months). There were 11 dropouts (14.5%) associated with tumor progression or hepatic decompensation (median waiting time; 5.4 months and range, 0.4-13 months). Cumulative probabilities of transplantation at three, six, nine, 12, 15, and 18 months were 5.4%, 35.4%, 67.5%, 78.8%, 80.7%, and 80.7%, respectively and those of waitlist dropout at three, six, nine, 12, 15, and 18 months were 3.9%, 8.7%, 12.8%, 22.9%, 29.3%, and 29.3%, respectively. A laboratory model for end-stage liver disease (MELD) score >15 or multiple tumors at the time of UNOS listing were significant risk factors for waitlist dropout (p = 0.006 and 0.026, respectively). Patients with HCC being managed with loco-regional therapy who have a laboratory MELD score >15 or multiple tumors should be considered for earlier access to liver transplantation to prevent waitlist dropout.
KW - Hepatocellular carcinoma
KW - Liver transplantation
KW - Loco-regional therapy
KW - MELD
KW - MELD exception points
KW - Waitlist dropout
UR - http://www.scopus.com/inward/record.url?scp=84864954136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864954136&partnerID=8YFLogxK
U2 - 10.1111/j.1399-0012.2012.01668.x
DO - 10.1111/j.1399-0012.2012.01668.x
M3 - Article
C2 - 22693962
AN - SCOPUS:84864954136
SN - 0902-0063
VL - 26
SP - E359-E364
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 4
ER -