TY - JOUR
T1 - Risk factors associated with Hepatitis E virus infection in kidney transplant recipients in a single tertiary Center in the United States
AU - Sakulsaengprapha, Vorada
AU - Wasuwanich, Paul
AU - Thawillarp, Supharerk
AU - Ingviya, Thammasin
AU - Phimphilai, Premporn
AU - Sue, Paul K.
AU - Jackson, Annette M.
AU - Kraus, Edward S.
AU - Teshale, Eyasu H.
AU - Kamili, Saleem
AU - Karnsakul, Wikrom
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/6
Y1 - 2023/6
N2 - Background: Hepatitis E virus (HEV), the causative agent of hepatitis E, is a common but self-limiting disease. However, in immunosuppressed kidney transplant 47 recipients (KTRs), HEV infection can become chronic. We investigated risk factors associated with HEV infection among 271 KTRs at the Johns Hopkins Hospital transplanted between 1988 and 2012. Methods: HEV infection was defined as having positive anti-HEV IgM, anti-HEV IgG, or HEV RNA. The risk factors included: age at transplant, sex, hemodialysis/peritoneal dialysis, plasmapheresis, transfusions, community urbanization, and other socioeconomic factors. Logistic regression was used to determine independent risk factors associated with HEV infection. Results: Out of 271 KTRs, 43 (16%) had HEV infection though not active disease. HEV infection in KTRs was associated with older age (≥45 years; OR = 4.04; 95% CI = 1.81–57 10.03; p = 0.001) and living in communities with low proportions of minorities (OR = 0.22; 95% 58 CI = 0.04–0.90; p = 0.046). Conclusion: KTRs who had HEV infection may be at an increased risk of developing chronic HEV.
AB - Background: Hepatitis E virus (HEV), the causative agent of hepatitis E, is a common but self-limiting disease. However, in immunosuppressed kidney transplant 47 recipients (KTRs), HEV infection can become chronic. We investigated risk factors associated with HEV infection among 271 KTRs at the Johns Hopkins Hospital transplanted between 1988 and 2012. Methods: HEV infection was defined as having positive anti-HEV IgM, anti-HEV IgG, or HEV RNA. The risk factors included: age at transplant, sex, hemodialysis/peritoneal dialysis, plasmapheresis, transfusions, community urbanization, and other socioeconomic factors. Logistic regression was used to determine independent risk factors associated with HEV infection. Results: Out of 271 KTRs, 43 (16%) had HEV infection though not active disease. HEV infection in KTRs was associated with older age (≥45 years; OR = 4.04; 95% CI = 1.81–57 10.03; p = 0.001) and living in communities with low proportions of minorities (OR = 0.22; 95% 58 CI = 0.04–0.90; p = 0.046). Conclusion: KTRs who had HEV infection may be at an increased risk of developing chronic HEV.
KW - Hepatitis E virus
KW - Kidney transplantation
KW - Risk factors
KW - Seroepidemiologic studies
UR - http://www.scopus.com/inward/record.url?scp=85150061676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85150061676&partnerID=8YFLogxK
U2 - 10.1016/j.trim.2023.101809
DO - 10.1016/j.trim.2023.101809
M3 - Article
C2 - 36863665
AN - SCOPUS:85150061676
SN - 0966-3274
VL - 78
JO - Transplant Immunology
JF - Transplant Immunology
M1 - 101809
ER -