Abstract
We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in both transmission and reflection modes. These systems used intense acoustic bursts and a charge-coupled device camera-based speckle contrast detection method. By mounting an ultrasound transducer into an optical condenser, we can combine the illuminating light component with the ultrasound transducer. Thus, the UOT system is more clinically applicable than previous orthogonal mode systems. Furthermore, we have successfully imaged an ex vivo methylene-blue-dyed sentinel lymph node (SLN) embedded deeper than 12 mm, the mean depth of human sentinel lymph nodes, in chicken breast tissue. These UOT systems offer several advantages: noninvasiveness, nonionizing radiation, portability, cost-effectiveness, and possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT systems is mapping SLNs in axillary staging for breast cancer patients.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 7177 |
| DOIs | |
| State | Published - 2009 |
| Event | Photons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States Duration: Jan 25 2009 → Jan 28 2009 |
Other
| Other | Photons Plus Ultrasound: Imaging and Sensing 2009 |
|---|---|
| Country/Territory | United States |
| City | San Jose, CA |
| Period | 1/25/09 → 1/28/09 |
Keywords
- Axillary lymph node dissection
- Breast cancer
- Ring-shaped light illumination
- Sentinel lymph node biopsy
- Ultrasound-modulated optical tomography
ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics