TY - JOUR
T1 - Review of biological effects of acute and chronic radiation exposure on caenorhabditis elegans
AU - Dhakal, Rabin
AU - Yosofvand, Mohammad
AU - Yavari, Mahsa
AU - Abdulrahman, Ramzi
AU - Schurr, Ryan
AU - Moustaid-Moussa, Naima
AU - Moussa, Hanna
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/8
Y1 - 2021/8
N2 - Knowledge regarding complex radiation responses in biological systems can be enhanced using genetically amenable model organisms. In this manuscript, we reviewed the use of the nematode, Caenorhabditis elegans (C. elegans), as a model organism to investigate radiation’s biological effects. Diverse types of experiments were conducted on C. elegans, using acute and chronic exposure to different ionizing radiation types, and to assess various biological responses. These responses differed based on the type and dose of radiation and the chemical substances in which the worms were grown or maintained. A few studies compared responses to various radiation types and doses as well as other environmental exposures. Therefore, this paper focused on the effect of irradiation on C. elegans, based on the intensity of the radiation dose and the length of exposure and ways to decrease the effects of ionizing radiation. Moreover, we discussed several studies showing that dietary components such as vitamin A, polyunsaturated fatty acids, and polyphenol-rich food source may promote the resistance of C. elegans to ionizing radiation and increase their life span after irradiation.
AB - Knowledge regarding complex radiation responses in biological systems can be enhanced using genetically amenable model organisms. In this manuscript, we reviewed the use of the nematode, Caenorhabditis elegans (C. elegans), as a model organism to investigate radiation’s biological effects. Diverse types of experiments were conducted on C. elegans, using acute and chronic exposure to different ionizing radiation types, and to assess various biological responses. These responses differed based on the type and dose of radiation and the chemical substances in which the worms were grown or maintained. A few studies compared responses to various radiation types and doses as well as other environmental exposures. Therefore, this paper focused on the effect of irradiation on C. elegans, based on the intensity of the radiation dose and the length of exposure and ways to decrease the effects of ionizing radiation. Moreover, we discussed several studies showing that dietary components such as vitamin A, polyunsaturated fatty acids, and polyphenol-rich food source may promote the resistance of C. elegans to ionizing radiation and increase their life span after irradiation.
KW - Acute and chronic exposure
KW - Biological dosimeter
KW - Caenorhabdi-tis elegans
KW - Dose
KW - Ionizing radiation
UR - http://www.scopus.com/inward/record.url?scp=85113510306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113510306&partnerID=8YFLogxK
U2 - 10.3390/cells10081966
DO - 10.3390/cells10081966
M3 - Review article
C2 - 34440735
AN - SCOPUS:85113510306
SN - 2073-4409
VL - 10
JO - Cells
JF - Cells
IS - 8
M1 - 1966
ER -