Review of biological effects of acute and chronic radiation exposure on caenorhabditis elegans

Rabin Dhakal, Mohammad Yosofvand, Mahsa Yavari, Ramzi Abdulrahman, Ryan Schurr, Naima Moustaid-Moussa, Hanna Moussa

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Knowledge regarding complex radiation responses in biological systems can be enhanced using genetically amenable model organisms. In this manuscript, we reviewed the use of the nematode, Caenorhabditis elegans (C. elegans), as a model organism to investigate radiation’s biological effects. Diverse types of experiments were conducted on C. elegans, using acute and chronic exposure to different ionizing radiation types, and to assess various biological responses. These responses differed based on the type and dose of radiation and the chemical substances in which the worms were grown or maintained. A few studies compared responses to various radiation types and doses as well as other environmental exposures. Therefore, this paper focused on the effect of irradiation on C. elegans, based on the intensity of the radiation dose and the length of exposure and ways to decrease the effects of ionizing radiation. Moreover, we discussed several studies showing that dietary components such as vitamin A, polyunsaturated fatty acids, and polyphenol-rich food source may promote the resistance of C. elegans to ionizing radiation and increase their life span after irradiation.

Original languageEnglish (US)
Article number1966
Issue number8
StatePublished - Aug 2021
Externally publishedYes


  • Acute and chronic exposure
  • Biological dosimeter
  • Caenorhabdi-tis elegans
  • Dose
  • Ionizing radiation

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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